The epicardium is the outermost layer of the heart and it is formed by mesothelial cells that derive from a transient structure of precursor cells (the proepicardium). Proepicardial cells migrate over the postlooped heart, followed by migration of committed endothelial and smooth muscle precursors ...
The contribution of the epicardium, the outermost layer of the heart, to cardiac regeneration has remained controversial due to a lack of suitable analytical tools. By combining genetic marker-independent lineage-tracing strategies with transcriptional profiling and loss-of-function methods, we report he...
The epicardium is essential for muscle regeneration in the zebrafish model of innate heart regeneration, and the epicardium also participates in fibrotic responses in mammalian hearts. This structure serves as a source of crucial cells, such as vascular smooth muscle cells, pericytes, and fibroblasts,...
The epicardium is the cardiac structure with perhaps the highest proliferative and regenerative capacity after birth. Both mammals and fish vigorously activate epicardial cells via epithelial-to-mesenchymal transition in response to damage [66,67]. A genetic fate-mapping study in mice showed that compa...
These three components enable mechanical unity of cardiomyocytes and a direct pathway of spreading action potentials. Because of this, the myocardium is observed as a form of syncytium, rather than a group of somewhat independent cells. Although the structure of myocardium is the same in the ...
The pericardium's structure allows it to withstand various physiological and pathological conditions, maintaining the heart's position in the thorax. The epicardium, however, contributes significantly to the metabolic needs of the heart by providing a protective layer that contains essential blood vessels...
Structure and Function of the Diastolic Heart: Material Properties of Passive Myocardium A considerable body of indirect evidence indicates that the characteristics and extent of the extracellular connective tissue matrix in the heart are important determinants of ventricular function. An appropriate constitut...
[The antagonistic function of the heart muscle sustains the autoregulation according to Frank and Starling : Part I: Structure and function of heart muscle]. Lunkenheimer PP, Niederer P, Lunkenheimer JM, Keller H, Redmann K, Smerup M, Anderson RH. Herz. 2020 Apr;45(2):170-177. doi:...
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1A. Similar to cardiac cell cluster cultures grown in monolayer (Polinger, 1973), a subpopulation of cells migrated from the slices and formed a halo-like structure on the periphery of the slice (data not shown). These migratory cells fail to express the cardiac myocyte marker myosin heavy ...