15.The main features of the system are as follows: computer real-time mapping of several points sampling of 53 points of epicardium; 系统具有以下特点:自动显示和绘出心外膜激动顺序图;网套电极对53个区全部采样; 16.The study "provides strong evidence that there is a population of cells from the...
When this layer comes into contact with the heart (not the great vessels), it is known as the epicardium.en.wikipedia.org On further investigation they discovered that a protein was driving stem cells in the epicardium to become fibroblasts.www.medicalnewstoday.com Hemorrhagic smallpox also produ...
EpiSCs are also known to migrate into the infarcted area of the heart where they can differentiate into multiple cell types such as endothelial cells, smooth muscle cells and fibroblasts8 to support the cardiac healing process4. Thus, the activated epicardium is a multipotent cell population with...
At least three transcription factors are known to be activated during epicardial EMT and to be essential to this process. These are sox9 (also expressed in cardiac valves), rxra (a retinoic acid receptor), and wt1. wt1 is widely used as a marker of the epicardium and is expressed in most...
a process that is greatly expanded in response to cryoinjury. Using single-cell RNA sequencing (scRNA-seq), we identify the tight junction protein CLDN6 as a specific marker of the homeostatic epicardium. Following cryoinjury, epicardium-derived cells (EPDCs) migrate to the injury site, form ...
Note also that the number and appearance of the nuclei is dramatically reduced after removal of the epicardium for 4 days (h), but not after culture of either the intact heart slice (d) or after removal of the endocardium and trabeculae (j) for the same period of time. (B) Quantitation...
The Human Heart The heart is a muscular organ that forms part of the cardiovascular system. The heart is located in the thoracic cavity, in the region called the mediastinum. The pumping action of the heart caused by depolarization...
(epicardium-derived stromal cells) to signify that the regeneration potential of EpiSC may be different from embryonic EPDCs6,7. EpiSCs secrete numerous paracrine factors that strongly promote angiogenesis and EpiSC-conditioned medium was shown to reduce infarct size4. EpiSCs are also known to ...
In vivo, CMs closest to the epicardium generate shorter action potentials than those in the middle of the ventricular wall; this is an evolutionarily conserved feature known as the transmural voltage gradient, which increases the efficiency of ventricular contraction27. We assessed action potential ...
This is of particular relevance when working with AVC explants from E10.5 embryos as they are prone to epicardial cell contamination. Besides confounding interpretations on cell identity, the epicardium is also a source of factors that may on their turn interfere with the process of EndoMT (e.g...