An alternative approach involves resident progenitor cells that become activated following injury and differentiate into cardiomyocytes. Epicardium, the epithelial layer enclosing the heart, is a prime candidate for such an approach as it is a source of multipotent progenitors during development17,18. Stu...
As mentioned, all of the cell populations arising from the epicardium are collectively known as EPDCs.91 As identified by lineage markers, EPDCs migrate into the AV sulcus matrix and from there into the AV endocardial cushions.47 In addition to entering the AV cushions, EPDCs were also note...
When this layer comes into contact with the heart (not the great vessels), it is known as the epicardium.en.wikipedia.org On further investigation they discovered that a protein was driving stem cells in the epicardium to become fibroblasts.www.medicalnewstoday.com Hemorrhagic smallpox also produ...
In vivo, CMs closest to the epicardium generate shorter action potentials than those in the middle of the ventricular wall; this is an evolutionarily conserved feature known as the transmural voltage gradient, which increases the efficiency of ventricular contraction27. We assessed action potential ...
This is the first time that human EPDC transcriptomes have been described at a single-cell resolution, as determined by their expression of mesenchymal genesTWIST1andSPARCas well as the combined expression of known epicardial and fibroblast genes. These characteristics are shared with cell populations...
While RNA sequencing data has been used to identify putative players in hESC-EPIs, little is known about their involvement in mediating hESC-CM maturation and revascularization, in particular in communication with endothelial cells (EC). Here, the role of paracrine signalling in hESC-EPI-mediated...
(nucEGFP) driven by the regulatory sequence oftcf2118. As shown in Fig.1a, b,tcf21+nuclei reside in multiple layers of the uninjured ventricular wall. While the outermost layer expressesaldh1a2(it is expressed in the endocardium as well; see also ref.18), the inner layers oftcf21+...
Once the epicardium is established, epicardial cells will directly start to participate in the formation of the cellular composition of the myocardium. A subset of the epicardial cells will undergo a process known as epithelial-to-mesenchymal transition (EMT) (reviewed in [42]; Fig. 1). EMT st...
However, it is unknown whether epicardial NRP2 is soluble or membrane-anchored as part of this established pathway of angiogenesis40,41. We also found further evidence of WNT signaling from the epicardium, with WNT2B communication between fetal epicardium and FZD4 found on adult endocardial, ...
While the pericardium consists of two main layers: the fibrous pericardium and the serous pericardium (which further divides into the parietal and visceral layers, the latter also known as the epicardium), the epicardium itself is a thin layer of tissue that lies just beneath the visceral layer ...