autophagy-related genes, ultimately influencing their transcription. Collectively, this study reveals EPB41L4A-AS1 as an AD-related lncRNA via mediating Aβ clearance and provides insights into the epigenetic regulatory mechanism of EPB41L4A-AS1 in gene expression and AD pathogenesis. © 2024. The...
We found that EPB41L4A-AS1 regulates the expression of general control of amino acid synthesis 5-like 2, an important histone acetyltransferase, thus affecting histone acetylation, crotonylation, and lactylation near the transcription start site of autophagy-related genes, ultimately influencing their ...
Here we aimed to investigate the role of lncRNA EPB41L4A-AS1 on placental trophoblast cell metabolic reprogramming, which might be involved in the pathogenesis of RM. After microarray and GEO database analyses, we found that EPB41L4A-AS1 was significantly increased in early RM placental tissue...
Aging and neurodegenerative diseases are typical metabolic-related processes. As a metabolism-related long non-coding RNA, EPB41L4A-AS has been reported to be potentially involved in the development of brain aging and neurodegenerative diseases. In this
本发明同时公开了一种治疗急性髓系白血病的药物组合物和一种评价LncRNA EPB41L4AAS1的试剂盒.本发明的药物组合物对急性髓系白血病有较好的抑制作用,在急性髓系白血病治疗中具有重要的参考和现实意义.本发明的试剂盒能够LncRNA EPB41L4AAS1的表达水平的评价手段之一,对LncRNA EPB41L4AAS1作为药物组合物应用时具有...
目的探讨长链非编码RNA EPB41L4A-AS1通过AKT调控子宫颈癌细胞自噬的作用和机制.方法运用小干扰RNA(siRNA)敲低子宫颈癌细胞HeLa中的EPB41L4A-AS1后,应用Western blot技术检测p62,LC3和AKT的蛋白表达水平,qRT-PCR检测AKT1和AKT2的mRNA表达水平.在GFP-LC3稳定过表达的HeLa细胞中转染siEPB41L4A-AS1,利用共聚焦扫描...
Overexpression of EPB41L4A-AS1 inhibited the activity of gastric cancer cells, while knockdown of EPB41L4A-AS1 promoted tumor deterioration. EPB41L4A-AS1 directly targeted and regulated the expression ofmiR-17-5p. Conclusion: This study elaborated that EPB41L4A-AS1 is lowly expressed in gastric...
EPB41L4A-AS1表达水平明显低于癌旁组织和健康体检正常者,差异有统计学意义(P<0.05).GEPIA数据库结果显示,胃癌组织中LncRNA EPB41L4A-AS1表达水平明显低于正常组织(P<0.05).T3～T4浸润深度,TNM分期Ⅲ～Ⅳ期,低分化,脉管侵袭,淋巴结转移及远处转移患者癌组织中LncRNA EPB41L4A-AS1表达水平均明显低于T1～T2浸润...
1.一种长链非编码RNA,所述长链非编码RNA为LncRNA EPB41L4A-AS1,其特征在于,LncRNA EPB41L4A-AS1在制备治疗急性髓系白血病的产品中的用途。 2.根据权利要求1所述的用途,其特征在于,所述的LncRNA EPB41L4A-AS1如SEQ IDNO.1所示。 3.根据权利要求1所述的用途,其特征在于,所述的LncRNA EPB41L4A-AS1的靶...
The bioinformatics approach was used to identify targeting miRNA for EPB41L4A-AS1 and UNC5B-AS1. Kaplan鈥揗eier survival curves and Whitney Mann U tests were conducted for validating the statistical significance. In cell culture experiments, the influence of EPB41L4A-AS1 and UNC5B-AS1 on ...