Epac has two isoforms: Epac1 and Epac2. The function of Epac1 on obesity was unveiled using Epac1 knockout (KO) mice. However, the role of Epac2 in obesity remains unclear. METHODS: To evaluate the role of Epac2 in obesity, we used Epac2a KO mice, which is dominantly expressed in ...
Finally, stimulation with forskolin prolonged beta cell activity during deactivation, especially in Epac2A knockout mice.Klemen, Maa SkelinDolenek, JurijBombek, Lidija KrianiPohorec, ViljemGosak, MarkoRupnik, Marjan SlakStoer, AndraFrontiers in Endocrinology...
Using advanced microscopy techniques, the researchers have now discovered that cyclic AMP triggers movement of Epac2A to the sites at the cell membrane where insulin vesicles are prepared for release, and that the amount of Epac2A at the vesicles controls how much insulin is released. Strikingly,...
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Epac2A also interacts directly and indirectly with the exocytotic machinery and likely forms a cAMP compartment in a specialized region of the pancreatic 尾-cell. In addition, Epac2A is activated by sulfonylureas (SUs), widely used anti-diabetic drugs. SU-stimulated insulin secretion is reduced ...
The Effect of cAMP and the Role of Epac2A During Activation, Activity, and Deactivation of Beta Cell Networksdoi:10.20944/PREPRINTS202105.0064.V1Skelin Klemen MDolenek JKriani Bombek LPohorecGosak MSlak Rupnik MStoer APreprints
cAMP is now known to potentiate insulin secretion by both protein kinase A (PKA)-dependent and PKA-independent mechanisms, the latter involving Epac2A, a protein possessing guanine nucleotide exchange factor activity towards the small G-protein Rap. Total internal reflection fluorescence microscopy ...