因为已经探索得知CREBBP/EP300突变会激活NOTCH信号通路,为了探索NOTCH信号通路的激活是否促进M2巨噬细胞极化,作者引入了NOTCH的抑制剂GSH-I,结果表明抑制剂明显抑制了CCL2和CSF1的蛋白表达,无论是在敲低还是在突变组(前面已经证实这两种变化均会引起CCL2和CSF-1的蛋白和转录水平上调),也就是说CREBBP/EP300突变引起的...
最近的研究表明,CREBBP和EP300突变与DLBCL患者外周细胞减少有关,并且与特定类型的TME相关。 在DLBCL患者中,CREBBP和EP300突变与外周血白细胞和单核细胞的比率降低有关。这表明这些突变可能影响免疫细胞的募集或存活。在具有CREBBP和/或EP300突变的DLBCL中,TAM呈现出M2样极化,即所谓的DP-LME。这可能与NOTCH通路的...
In cultured podocytes, pCPT-cAMP, a selective cAMP-PKA activator, dramatically blocked ADR-induced activation of Notch3 signaling as well as inhibition of cAMP-PKA pathway, thus alleviating the decreased cell viability and podocyte dedifferentiation. Bioinformatics analysis revealed EP300/CBP, a ...
原文标题:CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis 中文标题:CREBBP…
Category Protein Acetylation; Notch Signaling; Hypoxia Signaling; Epigenetics Background CBP (CREB-binding protein) and p300 (EP300) are highly conserved and functionally related transcriptional co-activators that associate with transcriptional regulators and signaling molecules, integrating multiple signal tr...
CREBBP/EP300mutations inhibited H3K27 acetylation and activated the NOTCH signaling pathway The possible structure–function relationship between CREBBP and EP300 was addressed using the crystal structure of the protein (Fig.3a). For example, CREBBP A1164V and R1169C, EP300 Y1139C disrupted the ...
(0℃,Type 1,Edgewise,Notch A) 4 Kj/cm Charpy无缺口冲击强度 (-20℃,Type 1,Edgewise) 110 Kj/cm ISO 179 弯曲模量 1250 MPa ISO 527-1,-2 Charpy无缺口冲击强度 ISO 179 (0℃,Type 1,Edgewise) 160 Kj/cm (23℃,Type 1,Edgewise) No Break Kj/cm 球压痕硬度 (H 358/30) 53 MPa IS...
Enhanced Wnt signaling further activates the expression of miR-34, another promoter of osteoblast differentiation involved in the regulation of Notch signaling, resulting in a sophisticated cascade regu- latory network29. Osterix (Osx), a zinc finger transcription factor and critical regulator of ...
Notch AISO 1793Kj/cm2Charpy缺口冲击强度23℃,Type 1,Edgewise,Notch AISO 1797.5Kj/cm2Charpy缺口冲击强度0℃,Type 1,Edgewise,Notch AISO 1794Kj/cm2Charpy无缺口冲击强度-20℃,Type 1,EdgewiseISO 179110Kj/cm2弯曲模量<
Charpy缺口冲击强度 7.5 Kj/cm2 ISO 17923℃,Type 1,Edgewise,Notch A Charpy缺口冲击强度 4 Kj/cm2 ISO 1790℃,Type 1,Edgewise,Notch A Charpy缺口冲击强度 3 Kj/cm2 ISO 179-20℃,Type 1,Edgewise,Notch A Charpy无缺口冲击强度 No Break Kj/cm2 ISO 17923℃,Type 1,Edgewise Charpy无缺口冲击强度 ...