Eosinophilia in the blood and/or tissues is a feature of multiple disorders. Although the initial cause and the organs vary, there are only the following two major pathways that mediate eosinophilia: a cytokine-mediated increased differentiation and survival of eosinophils and a mutation-mediated ...
Background and Aim: Eosinophils are markers of the eosinophilic esophagitis (EoE) disease, and this work aimed to assess whether activation of eosinophils could be a noninvasive test to contribute for EoE diagnosis.Methods: The activation state of peripheral blood eosinophils in EoE patients and ...
2 Further work is required to determine the drivers of eosinophil subtypes and functions and their responses to eosinophil-targeted therapies. Eosinophils in Disease Eosinophils are implicated in a range of pathologic conditions (Figure 2B), and elevated blood counts should prompt further evaluation for...
capsulatum in an additional experi- mental model, we utilized the IL-5 transgenic mice. These animals exhibit ±constitutive eosinophilia in their blood and peripheral organs including the lungs (Figure 3a). Although the transgenic mice are on a BALB/c background, we have previously reported ...
pp 346–347 Cite this reference work entry Dictionary of Toxicology 199 Accesses Eosinophils are the specific kind of white blood cell, involved in the pathophysiology of several inflammatory and malignant disorders as well as innate immunity. They contribute to the innate immune response by secreting...
Historically, the horse eosinophil has been used to study basic eosinophil biology because of the considerable volume of blood required to obtain enough viable cells for reliable, repeatable experiments. This resulted in a large but disseminated body of literature pertaining to the structure and ...
In addition, using IL-22BP-deficient rats, we confirm that endogenous IL-22BP is effective at blocking protective actions of IL-22 during acute colitis. In conclusion, our study provides new important insights regarding the biology of IL-22 and IL-22BP in the gut and indicates that ...
Eosinophils are involved in tissue homeostasis. Herein, we unveiled eosinophils as important regulators of bone homeostasis. Eosinophils are localized in proximity to bone-resorbing osteoclasts in the bone marrow. The absence of eosinophils in ΔdblGATA
Blood eosinophilia occurs in response to soluble factors, namely, the cytokines interleukin (IL)-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-3 (Figure 1). IL-5 has been well established to be specific and essential to eosinophils, having a central role in promoting eo...
IL-5 is a defining cytokine product of Th2 CD4 T cells. The production of IL-5 by Th2 lymphocytes accounts for the eosinophilia accompanying Th2 cell-mediated immune responses characteristic of helminth infections and allergic diseases. Increases in blood IL-5 have been detectable in some, but...