Eosinophilia in the blood and/or tissues is a feature of multiple disorders. Although the initial cause and the organs vary, there are only the following two major pathways that mediate eosinophilia: a cytokine-mediated increased differentiation and survival of eosinophils and a mutation-mediated ...
Eosinophils are the specific kind of white blood cell, involved in the pathophysiology of several inflammatory and malignant disorders as well as innate immunity. They contribute to the innate immune response by secreting highly cytotoxic proteins from their secretory granules in opposition to bacteria, ...
Human eosinophils in an in vitro study have also been reported to be responsive to S100B [83], a possible blood marker in some GBM cases that is known to be released by CD8+ T cells, astrocytes, oligo- dendrocytes, and tumor cells [84-86]. However, the mechanisms by which ...
Define Eosinophils. Eosinophils synonyms, Eosinophils pronunciation, Eosinophils translation, English dictionary definition of Eosinophils. also e·o·sin·o·phile n. A white blood cell that functions in the immune response by releasing enzymes that can
capsulatum in an additional experi- mental model, we utilized the IL-5 transgenic mice. These animals exhibit ±constitutive eosinophilia in their blood and peripheral organs including the lungs (Figure 3a). Although the transgenic mice are on a BALB/c background, we have previously reported ...
Eosinophils are also involved in allergic responses and in the reactions involved in asthma. These latter functions are complex and they work in conjunction with other white blood cells, like basophils and mast cells, to accomplish these reactions. Eosinophilic...
2 Further work is required to determine the drivers of eosinophil subtypes and functions and their responses to eosinophil-targeted therapies. Eosinophils in Disease Eosinophils are implicated in a range of pathologic conditions (Figure 2B), and elevated blood counts should prompt further evaluation for...
Localization of eosinophils near osteoclasts in synovial tissue was detected independently in sections from 5 RA patients. b Correlation between the gene expression of eosinophil gene RNASE2 with osteoclast-related genes NFATC1 and ACP5 in the blood of RA patients (n = 34). c, d ...
C and D, Histogram and mean fluorescence intensity (MFI) of cell surface expression of molecules (GGT5, IL1RL1, and IL3RA) in blood eosinophils from patients with eosinophilic asthma and healthy subjects. E, Correlation between type 2 cytokines (IL4 and IL5) and selected molecules (TGM2,...
Historically, the horse eosinophil has been used to study basic eosinophil biology because of the considerable volume of blood required to obtain enough viable cells for reliable, repeatable experiments. This resulted in a large but disseminated body of literature pertaining to the structure and ...