Eosinophilic esophagitis (EoE) is an atopic condition of the esophagus that has become increasingly recognized. Diagnosis of the disorder is dependent on the patient’s clinical manifestations and must be confirmed by histologic findings on esophageal mu
S. Robinson, "Update on new biologics for intractable eosinophilic asthma: impact of reslizumab," Drug Design, Development and Therapy, vol. 12, pp. 1173- 1181, 2018.Jagdeep Sahota1,Douglas S Robinson. Update on new biologics for intractable eosinophilic asthma: impact of reslizumab [J]....
It does not serve as a review of their clinical efficacies.Areas covered: All four of the currently approved monoclonal antibodies (biologics) used in the treatment of severe asthma are discussed with reference to the known safety data garnered from clinical trials and real world evidence. A ...
73,74 In patients with asthma, a marker of plasma exudation, α2-macroglobulin, showed a strong correlation with sputum eosinophils.75 The combination of increased mucin secretion and vascular permeability provides resistance against protease-dependent degradation and increases the propensity for creation ...
Asthma is a heterogeneous disease commonly driven by allergic and/or eosinophilic inflammation, both of which may be present in severe disease. Most approved biologics for severe asthma are indicated for specific phenotypes and target individual downstream type 2 components of the inflammatory cascade. ...
9 Blockade of IL-5 is also found to be an effective treatment strategy for eosinophilic asthma.3, 4 Besides mepolizumab, one other humanized antibody (reslizumab, an IgG4κ antibody) that also binds to IL-5 and interferes with its binding to the IL-5 receptor has been approved by ...
In conclusion, among the already evaluated biologics, IL-13 and IL-4 blockers appear to represent the most promising approach in patients with refractory EoE. Dietary treatment of eosinophilic esophagitis Eosinophilic esophagitis is mainly induced by food proteins. Avoidance of a contact between the ...
Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis characterized by eosinophil-rich granulomatous inflammation and small-to-medium vessel vasculitis associated with asthma, rhinosinusitis, and eosinophilia. EGPA is often difficult ...
Treatment duration is inversely correlated with the relapse rate. Increased doses of inhaled corticosteroids, oral corticosteroids, and leukotriene receptor antagonists are recommended in persistent disease. Anti鈥揑L-5 biologics could be promising in this disease. Studies that investigate biomarkers for ...
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