Allergy, Asthma & Clinical Immunology volume 20, Article number: 72 (2024) Cite this article 899 Accesses Metrics details Abstract Eosinophilic esophagitis (EoE) is an atopic condition of the esophagus that has become increasingly recognized. Diagnosis of the disorder is dependent on the patient’s...
"Eosinophilic asthma" is a new terminology that has come to be used to describe an old concept of patients with asthma whose symptoms and severity are predominantly driven by the eosinophil. Quantitative sputum cytometry is the most validated and sensitive test for diagnosis of eosinophilic asthma....
Blood eosinophil count, Forced Expiratory Volume in 1 second, % of predicted (FEV1%), Fractional exhaled nitric oxide (FeNO), Asthma Control Test (ACT), oral steroid (OCS) intake and exacerbation rate were evaluated during mepolizumab treatment. Results: 69 patients were enrolled (mean age: ...
Analysis of publication bias displayed a relatively symmetrical fun- nel plot, while Egger's test showed no publication bias (P = 0.305). (Fig. 3B and Appendix 5B). Common AEs Nasopharyngitis, asthma worsening, headache, upper respiratory tract infection, and bronchitis were the 5 most ...
What is an‘‘eosinophilic phenotype’’of asthma? Parameswaran Nair,MD,PhD,FRCP,FRCPC Hamilton,Ontario,Canada Key words:Sputum eosinophils,blood eosinophils,fraction of ex-haled nitric oxide,asthma,phenotype The role of eosinophils as a key player in the pathophysiology of asthma has been debated,...
We retrospectively enrolled uncontrolled severe asthmatic patients who switched from OMA to MEP during the last two years. Information included blood eosinophil count, asthma control test (ACT), spirometry, serum IgE, fractional exhaled nitric oxide (FeNO), OCS intake, drugs, exacerbations/...
Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis characterized by eosinophil-rich granulomatous inflammation and small to medium vessel vasculitis associated with asthma, rhinosinusitis, and eosinophilia [1, 2]. Eosinophilic chr...
Eosinophilic leukocytes (eosinophils) are important effector cells in allergic inflammatory diseases such as asthma, in which significant accumulation of these cells is observed in the bronchial mucosa. However, there is little information about the relationships between bronchoconstriction and accumulation of...
Background/Aims Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus. Similar to asthma, EoE can induce irreversible structural changes in the esophagus as a result of chronic and persistent eosinophilic inflammation. The aim of this study was to analyse changes in sympt...
aTimeline of intravenous injection of mIL-5-anchored CCAR-T cells, OVA-aerosol administration for the asthma model, and sample analysis in BALB/c mice.bFlow cytometry analysis of Eos proportion in BALF.*P < 0.05,**P < 0.01 by two-tailed Welch’st-test.cCell count of Eos in BAL...