Eosinophilic esophagitis (EoE) is an atopic condition of the esophagus that has become increasingly recognized. Diagnosis of the disorder is dependent on the patient’s clinical manifestations and must be confirmed by histologic findings on esophageal mu
There's no cure for EoE. But treatment can help you manage the inflammation that causes symptoms. The main ways to do that are with diet changes and medication. Treatments include: An elimination diet.This involves removing certain foods that are common allergens from yourdiet,then adding them ...
Dupilumabis a biologic agent that is given by injection. It is a monoclonal antibody (an antibody that is produced in a laboratory from living cells).Dupilumabmay be given to people who are 1 year old and older who weigh at least 33 pounds (15 kilograms). This medication reduces ...
Eosinophils are terminally differentiated cells derived from hematopoietic stem cells (HSCs) in the bone marrow. Several studies have confirmed the effective roles of eosinophils in asthmatic airway pathogenesis. However, their regulatory functions have not been well elucidated. Here, increased C-C chemo...
It was hereby presumed that this discrepancy could result from effective treatment management during clinical trials, while real-world clini- cal assessments and medication applications might pre- sent increased complexity. The post-marketing analysis raises queries about the adequacy of asthma treatment ...
IntroductionWe investigated the effect of benralizumab, an interleukin-5 receptor alpha–directed cytolytic monoclonal antibody, on rescue medication use by patients with severe, uncontrolled asthma with eosinophilic inflammation.doi:10.1016/j.anai.2018.09.057O'Quinn, S....
A randomized trial undertaken by Leckie et al,19 in patients with mild asthma, found that a single injection of mepolizumab intravenously (IV, up to 10 mg/kg) could reduce eosinophil counts in the airway and blood for at least a month; however, it was not efficacious in improving forced ...
NUCALA is a prescription medicine for the treatment of people 12 years of age and older with hypereosinophilic syndrome (HES). When you have HES, your eosinophil [ee-uh-sin-uh-fil] levels are elevated. Elevated levels of eosinophils can lead to inflammation throughout your body. This inflamma...
case will aid in the diagnosis and treatment of similar cases. CASE PRESENTATlON Chief complaints The patient had no chronic illnesses such as hypertension, diabetes, or asthma, and no history of cancer.She was a non-smoker and did not habitually drink alcohol. She had a well-balanced diet ...
SummaryBackgroundMepolizumab, an anti-interleukin-5 monoclonal antibody approved as add-on therapy to standard of care for patients with severe eosinophilic asthma, has been shown in previous studies to reduce exacerbations and dependency on oral corticosteroids compared with placebo. We aimed to ...