Eosinophil peroxidase (EPX) is a major constituent of the large cytoplasmic granules of both human and mouse eosinophilic leukocytes. Human EPX deficiency is a rare, autosomal‐recessive disorder limited to the eosinophil lineage. Our intent was to explore the impact of EPX gene del...
上海爱萌优宁生物技术有限公司生产的 ELISA 试剂盒采用“夹心法”:将捕获抗体包被于酶标板上,捕获样品及标准品中的靶蛋白,生物素化的检测抗体与靶蛋白结合, SABC 复合物与生物素化检测抗体结合,形成免疫复合物,加入TMB 显色液后,若反应孔中有靶蛋白则显蓝色,加入终止液变黄色,检测过程中游离的成分均被洗去,用酶...
Eosinophil Peroxidase (EPX) EPXis an eosinophil-specific cationic protein that is localized in the matrix of the secondary granules. Synthesized as a single chain precursor, EPX is proteolytically processed into a heavy chain (50–57 kDa) and a light chain (11–15 kDa). Although EPX has 68 ...
Certificate EPO; EPP; EPX-PEN; EPER Product No.EPJ138Mu61 Organism SpeciesMus musculus (Mouse)Same name, Different species. SourceEukaryotic expression HostCHO Cell Endotoxin Level<1.0EU per 1µg (determined by the LAL method) Subcellular LocationCytoplasm ...
These proteins include major basic protein-1 and -2 (MBP-1, MBP-2), eosinophil peroxidase (EPX), eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN) (Fig. 1). The Charcot-Leyden crystal protein/Galectin-10 (CLC/Gal-10), although not cationic, is a hydrophobic auto...
Eosinophils release eosinophil peroxidase (EPX) and reduce the level of reactive oxygen species (ROS) and the phosporylation of mitogen-activated protein kinases (MAPKs) in osteoclast precursors (OCPs). In this way, eosinophils influence the homeostasis of bone and reduce pathological bone loss. ...
Paradoxically, the ablation of the two genes encoding the most abundant of these granule proteins, major basic protein-1 (MBP-1) and eosinophil peroxidase (EPX), results in a near collapse of eosinophilopoiesis. The specificity of this lineage ablation and the magnitude of the induced eosinopen...
Eosinophils release eosinophil peroxidase (EPX) and reduce the level of reactive oxygen species (ROS) and the phosporylation of mitogen-activated protein kinases (MAPKs) in osteoclast precursors (OCPs). In this way, eosinophils influence the homeostasis of bone and reduce pathological bone loss. ...
The use of eosinophil peroxidase (EPX) has been validated as an ideal and specific biomarker to identify the presence of eosinophils when compared to other surrogate markers11. While antibodies have already been developed for this target, recent research has shown that the possibility of an autoimmu...
The analysis of eosinophil shape change and mediator secretion is a useful tool in understanding how eosinophils respond to immunological stimuli and chemotactic factors. Eosinophils undergo dramatic shape changes, along with secretion of the granule-derived enzyme eosinophil peroxidase (EPX) in response ...