SUICIDE SUBSTRATES FOR SPECIFIC TARGET ENZYMESChristopher WalshProteins in Biology & Medicine
Although biosynthetic pathways of selenium-containing macromolecules have been known for decades, pathways for specific incorporation of selenium into small molecules have only recently begun to be uncovered. Now the selenometabolome is expanded further through the discovery and biosynthetic elucidation of ov...
Biocatalysts have many benefits for speeding up specific transformations, but the chemistry used by naturally occurring catalysts is limited. Pioneering work in 2016 used directed evolution to create heme-dependent enzymes able to form new silicon–carbon bonds, showcasing the approach’s power to atta...
Give a specific example. What would happen to chemical reactions without enzymes? What do enzymes have that determine their function? Why do enzymes only work on their specific substrates? How do enzymes initiate chemical reactions? Which enzyme catalyzes the reaction shown? What enzymes class is ...
The active site of an enzyme is veryspecificto its substrates as it has a veryprecise shape.This results in enzymes being able to catalyze only certain reactions as only a small number of substrates fit in the active site. This is called enzyme-substrate specificity. For a substrate to bind...
consequence of tumor formation [128,129]. Therefore, the role of RNA editing in cancer depends not only on the location and level of RNA editing information but also on the specific cancer type [130,131]. Although many studies have reported the connection between RNA editing and cancer, the...
This structural polysaccharide is a complex polymer, and only a specific set of enzymes can breakdown cellulose [3]. Many of these enzymes are produced by fungi, such as those of the genera Aspergillus, Neurospora and Trichoderma. Trichoderma harzianum is a filamentous fungus [4] and a ...
Among the human genome, there is only one E1, but fourteen E2s, and more than one thousand E3s. The E3 ubiquitin ligase is substrate-specific, and yet one E3 ligase may control the degradation of numerous substrate proteins [23]. On the other hand, one protein could be ubiquitinated by ...
Cells face various allocation problems demanding decisions on how to distribute their finite resources. They decide which enzymes to produce at what quantity, but also where to position them. Here we focus on the spatial allocation problem of arranging e
we only considered small molecules included among the experimentally confirmed enzyme-substrate pairs in our dataset. Among such a limited and biased subset, enzymes are quite specific catalysts, and therefore most of the potential secondary substrates are not included for the majority of enzymes. Thus...