linkers in peptide and nucleic acid synthesisIntroductionEnzyme cleavable linker unitsConclusion Referencesdoi:10.1002/9780470749043.ch7Mallesham BejugamSabine L. FlitschJohn Wiley & Sons, LtdReferences. Chapter 7: Enzyme Cleavable Linker Units (Mallesham Bejugam and Sabine L. Flitsch)....
Enzyme-cleavable linkers for peptide and glycopeptide synthesis. Hydroxymethylphenoxy linkers that are commonly used in solid phase peptide synthesis are surprisingly susceptible to efficient cleavage by the protease chy... A Beatrice,Maltman,Mallesham,... - 《Organic & Biomolecular Chemistry》 被引量...
For this purpose, some of the antibody-siRNA conjugates have been prepared using various degradable linkers to conjugate siRNA with antibodies, which can release siRNA near the target site [83,84]. With a rather complex design, EGFR antibody connected to CPP-EGFR siRNA via cleavable peptides (...
The goal of the current study was to investigate the use of brush border enzyme-cleavable linkers as a strategy for reducing kidney activity levels from radiolabeled PSMA inhibitors.Vaidyanathan, GanesanKang, Choong MoMcDougald, DarrylMinn, IlBrummet, MaryPomper, Martin G.Zalutsky, Michael R....
Bejugam, M.Flitsch, S. L.ORGANIC AND BIOMOLECULAR CHEMISTRYMaltman, B.A. et al. (2005) Enzyme-cleavable linkers for peptide and glycopeptide synthesis. Org. Biomol. Chem. 3, 2505-2507Maltman BA, Bejugam M and Flitsch SL, Enzyme-cleavable linkers for peptide and glycopeptide synthesis. ...
Basso, A. et al. (2005) Penicillin G-amidase-catalysed hydrolysis of phenylacetic hydrazides on a solid phase: a new route to enzyme- cleavable linkers. Adv. Synth. Catal. 347, 963-966Basso A,Ebert C,Gardossi L,et al.Penicillin G am i-dase-catalysed hydrolysis ofphenylacetic hydrazides ...
Basso A, Ebert C, Gardossi L, Linda P, Phuong TT, Zhu M, et al, Penicillin G amidase-catalysed hydrolysis of phenylacetic hydrazides on a solid phase: a new route to enzyme-cleavable linkers. Adv Synth Catal 347:963-966 (2005).
Enzyme cleavable linkersSolid-phase reactionsLPOSSeveral polymeric supports possessing an ester moiety were prepared and a range of enzymes was investigated to hydrolyse the ester linkage and release a signalling group into solution for applications in immunoassays . Pseudomonas lipases were found to most...
These results imply that a combination of enzyme- and reduction-responsive linkers can be used to solve the problems associated with the use of nonviral vectors.doi:10.1007/s13233-021-9078-4The Polymer Society of KoreaMacromolecular Research
For this purpose, some of the antibody-siRNA conjugates have been prepared using various degradable linkers to conjugate siRNA with antibodies, which can release siRNA near the target site [83,84]. With a rather complex design, EGFR antibody connected to CPP-EGFR siRNA via cleavable peptides (...