A Lysosome Enzyme is a type of hydrolytic enzyme found in lysosomes that functions to break down biological polymers delivered through processes like endocytosis and autophagy, maintaining cellular homeostasis by controlling macromolecule turnover.
Together, these IGF2-mediated effects on the functioning of cell surface and soluble CI-MPRs would result in more hydrolytic enzymes being present in extracellular fluids. IGF2 is synthesized as a pre-pro-protein that is processed in the ER and Golgi, with endoproteolysis occurring in the ...
Sertoli cells showed cyclical variations in their . These were present in small numbers from ... CHEMES HECTOR - 《Endocrinology》 被引量: 180发表: 1986年 Implication of phagosome-lysosome fusion in restriction of Mycobacterium avium growth in bone marrow macrophages from genetically resistant mice....
Acid hydrolases are present in normal human urine in appreciable amounts. Their source appears to be lysosomes released by kidney proximal tubule epithelial cells. For a given lysosomal enzyme the total amount excreted is the product of two parameters, a general one describing the rate of lysosome...
Furthermore, α-syn accumulations inCtsd-/- brains were present in cells co-expressing the neuron marker, neuronal nuclear antigen (NeuN), but not in glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes (Fig.1b–c). Accumulation of ubiquitinated proteins also occurs inCtsd-/- cortex...
targeted enzyme compounds and uses thereof abstract of the disclosure the present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and angiopep-2. in certain embodiments, these...
Whilst imiglucerase is designed to target the mannose-receptor by terminal mannose groups, previous work had demonstrated that it can bind to M6PR despite the low levels of M6P present in its glycans36. In contrast, uptake and efficacy of hGCase-hBS were unaffected in M6PR-CI KO cells (...
The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the su... De Almeida, Moreira Joo Nuno Sereno,Caldeira De, Moura Vera Lúcia Dantas Nunes,De Magalhes, Sérgio Paulo,... 被引量: 3发表: 2012年 HI...
The lysosome was discovered in 1955 by Christian de Duve. The first demonstration by Hers of a link between an enzyme deficiency and a storage disorder (Po... Dominique P. Germain - 《Médecine Sciences M/s》 被引量: 24发表: 2005年 Liposome-Templated Hydrogel Nanoparticles as Vehicles for ...
We produced RTB:IDUA using an Agrobacterium-mediated transient expression system in the leaves of Nicotiana benthamiana. Production of the non-toxic RTB lectin in a heterologous plant system elim- inates any possible ricin toxicity (no RTA is present). In addition, plant-based production systems ...