酶的特异性(Enzyme specificity)及活性位点的诱导契合模型(induced-fit model) 与工业化中用到的无机催化剂不同,酶在发挥作用时有高度的专一性。酶的活性位点中的氨基酸排布方式刚好使得能其与底物的某些化学基团发生结合,形成enzyme–substrate complex。 在enzyme–substrate complex形成之后,酶的活性位点结构会发生稍微...
1. Enzyme as biological catalyst2. Enzymes can be used repeatedly (酶可以重复使用)3. A small amount of enzyme is required4. Enzyme is a kind of protein5. affected by temperature and pH value of the environment. (酶会被温度,pH等影响)6...
Substrate specificity modified chimeric enzymePROBLEM TO BE SOLVED: To obtain a substrate-specific modified chimera enzyme and to provide a method for producing the enzyme.山本 拓生向井 和久山下 洋福田 恵温
M. I. Page, The specificity of enzyme-substrate interactions. In Accuracy in Molecular Processes (Eds T. B. L. Kirkwood, R. F. Rosenberger and D. J. Galas), pp. 37-66. Chapman & Hall, London (1986).RYAN, M. D.; BELSHAM, G. J.; KING, A. M.: ' Specificity of enzyme-...
Human APOBEC3A is a single-stranded DNA cytidine deaminase that restricts viral pathogens and endogenous retrotransposons, and has a role in the innate immune response. Furthermore, its potential to act as a genomic DNA mutator has implications for a rol
Enzyme Specificity In subject area: Medicine and Dentistry (3) Multisite substrate specificity describes interactions between a protein kinase and its substrate that occur outside of the kinase catalytic cleft. From: Methods in Enzymology, 2019 About this pageSet alert Also in subject areas: Biochemi...
Substrate Specificity of the Milk-clotting Enzyme from Irpex lacteus on κ- and β-Casein 喜欢 0 阅读量: 29 作者:Hideyuki Kobayashi,Isao Kusakabe,Saeko Yokoyama,Kazuo Murakami 摘要: Irpex lacteus milk-clotting enzyme hydrolyzed the Phe(105)-Met(106) bond of κ-casein, causing the precipitation...
Attachment of ubiquitin (Ub) to proteins is one of the most abundant and versatile of all posttranslational modifications and affects outcomes in essentially all physiological processes. RING E3 ligases target E2 Ub-conjugating enzymes to the substrate, resulting in its ubiquitination. However, the me...
1. The actions of p-phenylazobenzoyl Taka-amylase A (PhAB-TAA) on phenyl α-maltotrioside and on malto-oligosaccharides were compared with those of intact ... K Omichi,T Ikenaka,Y Matsushima - 《Journal of Biochemistry》 被引量: 0发表: 1972年 Studies on the substrate specificity of Taka...
Production of recombinant proteins by microbes and higher organisms. Biotechnol Adv. 2009;27(3):297–306. Article CAS PubMed Google Scholar Derst C, Henseling J, Röhm KH. Engineering the substrate specificity of Escherichia coli asparaginase. II. Selective reduction of glutaminase activity by ...