作者: Jung Kyoon Choi and Sang Cheol Kim 摘要: Phenotypic discordance between monozygotic twins, such as a difference in disease susceptibility, implicates the role of the environment in determining phenotype. To assess genomewide environmental effects on "gene expression phenotype," we employed a ...
As these examples illustrate, there are many specific instances of environmental influences on gene expression. However, it is important to keep in mind that there is a very complexinteractionbetween our genes and our environment that defines ourphenotypeand who we are. References and Recommended Rea...
Morgan DK & Whitelaw E (2009) The role of epigenetics in mediating environmental effects on phenotype. Nestle Nutr Workshop Ser Pediatr Program 63, 109-117; discus- sion 17-19, 259-268.Morgan DK, Whitelaw E: The role of epigenetics in mediating environmental effects on phenotype. Nestle ...
The Agouti Yellow mouse model, where maternal diet alters offspring gene expression and resultant clinical phenotypes [98], offers mechanistic insight into this connection between the maternal exposome and offspring phenotype. In the model, the female Agouti Yellow dam has an altered version of the a...
In recent years, increasing interest on the effects of dietary components on epigenetic processes and, consequently, on the regulation of gene expression and metabolic responses has led clinical efforts worldwide to approach obesity. When inadequate, foo
Consistent with previous findings reported inA. thaliana, the tobaccodpd1mutant does not display a noticeable vegetative growth phenotype. Plant growth, reproductive transition and floral development in thedpd1mutant were comparable to wild-type plants (Extended Data Fig.5a). However, a reduction in ...
In recent years there has also been accumulating evidence for what has been referred to as “thermal sex ratio distortions” or “anomalous GSD,” which applies to cases where environmental factors influence sex determination and/or differentiation, and ultimate sexual phenotype, but effects ...
and exert a large phenotypic effect often independent of environmental factors, complex genetic traits such as asthma and related allergic disorders are common and result from mild mutations in multiple genes each of which has a small effect on the phenotype and requires subtle gene-gene (epistasis...
L. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell. Biol. 23, 5293–5300 (2003). This study demonstrates that maternal methyl donor supplementation during gestation can alter offspring phenotype by methylating the epigenome. Article CAS PubMed Pub...
Modeling rice metabolism: From elucidating environmental effects on cellular phenotype to guiding crop improvement. Front. Plant Sci. 2016, 7, 1795. [Google Scholar] [CrossRef] [Green Version] Asada, K. The water-water cycle as alternative photon and electron sinks. Philos. Trans. R. Soc. ...