Endocytosis mediated by the actin cytoskeleton There is a growing understanding of the molecular mechanism involved in the operation of different endo- cytic pathways and the role for the actin cytoskeleton in
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Distinguishing features of exitrons Exitrons are defined as introns within protein-coding exons that, when retained, maintain the protein-coding potential of the transcript. Marquez and colleagues argue that four features distinguish exitrons from other introns: high GC content, absence of stop codons...
It is also well-known that many folded protein domains can engage in highly specific interactions with various species including small ligands and cofactors, IDPs, IDRs on multidomain proteins, other folded proteins, and oligonucleotides (e.g., RNA and DNA). The following studies establish that ...
Endocytosis occurs at the cell surface and involves internalization of the plasma membrane (PM) along with its constituent membrane proteins and lipids. Endocytosis is involved in sampling of the extracellular milieu and also serves to regulate various p
Air–liquid interface (ALI) cultures support murine astrovirus replication As the 3D enteroids did not support muAstV replication, we utilized the 3D murine enteroid cells to form 2D monolayers on transwells under ALI conditions (Fig. 3A). We added FFT from Rag2−/−Il2rg−/− mice...
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Where are DNA and RNA located in the cell? Explain transcription and how the pre-mRNA is processed. Why do RNA viruses mutate faster than DNA? Describe how the RNA transcript is modified before it can be used to make proteins. Relating to biology, explain the term 'RNA polymerases'. ...
We found that xenograft tumors that emerged following a chemotherapy-induced DTP state did not exhibit any significant decrease in genetic or barcode complexity. Furthermore, mathematical modeling supported the “equipotent” model, in which all cancer cells in a given tumor have an equal capacity ...
Following a three-month period, the average difference in the AIS score constituted the principal outcome. Secondary outcomes involved the average changes in ESS and PDQ-5 scores, assessed over a 3-month duration. The comparison of pre- and post-diazepam equivalents was also performed by us....