Enkephalinase is a neutral aminopeptidase enzyme (EC 3.4.24.11), initially thought to be responsible only for degradation of released enkephalins. It does, however, metabolize other peptides, and enkephalins are also subject to degradation by other peptidases. Nonetheless, direct application of ...
This enzyme termed "enkephalinase" was detected in other tissues and was shown to be particularly enriched in the kidney cortex. Its identity with Neutral Endopeptidase (NEP: E.C.3.4.24.11), has been established using specificity, sensitivity to inhibitors and immunological criteria5. Both renal ...
An enkephalinase inhibitor is a compound that blocks the activity of enzymes responsible for degrading enkephalins, thereby prolonging the duration of enkephalin action and potentially serving as a promising target in chronic pain treatment within the field of Neuroscience. ...
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发明名称: ENKEPHALINASE INHIBITORS 发明人: DELANEY, NORMA G.;GORDON, ERIC M. 申请人: 申请日期: 1985-03-28 申请公布日期: 1987-12-03 代理机构: 代理人: 地址: 摘要: 二、法律状态 暂无信息 三、权利要求 暂无信息 四、说明书暂无信息 打开APP,查看更多专利的权利要求、说明书更多...
Acetorphan, an enkephalinase inhibitor, modulates dopaminergic transmission in rat olfactory tubercle, but not in the nucleus accumbens and striatum. Eur J Neurosci 2:783-787, 1990.N. Dourmap, A. Michael-Titus, and J. Costentin, "Acetor- phan, an enkephalinase inhibitor, modulates ...
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Because enkephalinase has its active site located extracellularly and is thus an ectopeptidase, we suggest that the N-terminal transmembrane region of the enzyme anchors the protein in membranes and that the majority of the protein, including the carboxy terminus, is extracellular. Enkephalinase, a...
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Budd K., 1985, " The use of the opiate antagonist, naloxone, in the treatment of intractable pain. " Neuropeptides. 5(4-6):419-22.Budd, K. (1983). Use of D-phenylalanine, an enkephalinase inhibitor, in the treatment of intractable pain. In Bonica, J.J., Lindblom, V., and Iggo...