Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D) mice. Eur J Neurosci. 2008; 28 :625–632.Rutten K, et al. Enhanced long-term potentiation and impaired learning in phosphodiesterase,4D-knockout (PDE,4D) mice. Eur J Neurosci. 2008; 28 :625–632...
In the present study, we found that Dorfin interacts with the abundant excitatory postsynaptic scaffolding protein PSD-95.Dorfin−/−mice show suppressed adult neurogenesis and enhanced long-term potentiation (LTP) in the dentate gyrus (DG) and impaired contextual fear conditioning, suggesting that ...
including at high levels in the nervous system, especially in neurons and glial cells, and while previous studies have established a neuroprotective role, conflicting evidence for a synaptic function has revealed both reduced and enhanced long-term potentiation, and variable observations on memory, lear...
Mutant mice exhibit enhanced long-term potentiation (LTP) in the CA1 region of hippocampal slices and impaired spatial learning abilities in an age-... Niisato,K. - 《Journal of Neuroscience the Official Journal of the Society for Neuroscience》 被引量: 145发表: 2005年 Impaired learning with ...
conflicting evidence for a synaptic function has revealed both reduced and enhanced long-term potentiation, and variable observations on memory, learning, and behavior. Such evidence has been confounded by the absence of an appropriate knock-out mouse model to dissect the biological relevance of PrPC...
Enhanced cAMP response element-binding protein activity increases neuronal excitability, hippocampal long-term potentiation, and classical eyeblink conditi... Enhanced cAMP response element-binding protein activity increases neuronal excitability, hippocampal long-term potentiation, and classical eyeblink ...
Our results indicate that CA1 hippocampal long-term potentiation (LTP) is enhanced in slices prepared from juvenile, but not adult, Cdkl5−/y rats. Enhanced LTP does not result from changes in NMDA receptor function or subunit expression as these remain unaltered throughout development. Further...
Using dendritic and somatic whole-cell recordings, combined with calcium imaging in rat hippocampal slices, we found that the induction of long-term potentiation (LTP) was accompanied by a local increase in dendritic excitability that was dependent on the activation of NMDA receptors. These changes ...
Long-term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia. Eur J Neurosci 2005;21:2384-2396. [PubMed: 15932597]Rodriguez J.J,Davies H A,Silva A.T, et al.Long-term potentiation in the rat dentate gyrus is ...
neurogenesis, enhanced long-accepted: 14October 2015 Published: 10 November 2015 term potentiation, and impaired contextual fear conditioningwith PDZ domains from PSD-95 relatives (PSD-93/Chapsyn-110, SAP97, SAP102), but not with those from S-SCAM, GRIP2, or Shank1. A mutant Dorfin, in ...