Thermal energy of MNPs in response to an AMF has inspired researchers to devise an on-demand drug release system that uses remote magnetothermal actuation [120,203]. Because the driving force of drug loading for conventional MNP-based drug cargo systems depends largely on the physical or electros...
Female BALB/c nude mice ∼ 4 weeks old were purchased from the Shanghai Experimental Animal Center (Shanghai, China). A549 cells were injected subcutaneously into the right flank of nude mice to establish the tumor xenograft model. When the tumors grew to 80–120 mm3 in size, mice were ...
The same applies to the wire hang test [50] which is not muscle-specific, as it recruits whole animal muscles as well as balance abilities to resist hanging fatigue. As for exhaustion tests using wheels or treadmills [28, 52], although they appropriately reflect DMD functional ambulatory ...
We discovered that MePS2 modification further enhances the loading of siRNAs to RISC, compared with PS2 modification, resulting in enhanced silencing. While the addition of methyl groups typically elevates Tm, we show here that the addition of 20-OMe to PS2-modified siRNAs does not increase the...
Skin wound infection has become a notable medical threat. Herein, the polysaccharide-based injectable hydrogels with multifunctionality were developed by a simple and fast gelation process not only to inactivate bacteria but also to accelerate bacteria-i
Seventy-day-survival of the different animal groups were 100% (control, CKD and CKD-Li), and 50% (CKD-MI/R, CKD-MI/R-Li) (Fig. 2). Serum creatinine and urine output were significantly increased during CKD progression compared with the controls 2–8 weeks after 5/6 nephrectomy (p...
The efficacy of this therapy has yet to be demonstrated in animal paradigms. This study demonstrates for the first time that an immunotherapy-based approach using CIK cells could be effective to treat RB, mainly because it has selective effect on carboplatin-resistant retinoblastoma cells. Thus ...
However, there is currently no vaccine or therapeutic reagent in clinical use, although some reports have demonstrated effective vaccination strategies for CVB3 in animal models. These include inactivated virus, attenuated live virus, DNA vaccines, and virus-like particle (VLP) vaccines4–16. These ...
in both contrasts is in agreement with the findings of Walker-Samuel et al.3, who did not observe a significant correlation between glucoCEST and GdCE-T1w contrast in an animal study. This allows for the conclusion that DGE-MRI can provide complementary information about pathologies compared to...
A“patient,”“subject,” or “individual” are used interchangeably and refer to either a human or a non-human animal. These terms include mammals, such as humans, primates, livestock animals (including bovines, porcines, etc.), companion animals (e.g., canines, felines, etc.) and rode...