The role of the gut microbiome in human health and disease is being increasingly recognized. Gut microbes (including bacteria, fungi and viruses) can be genetically modified to diagnose (as biosensors) and treat (detoxification, controlled biosynthesis and precision targeting) the dysbiosis of the mic...
How the different intrinsic and extrinsic factors such as host genetics, mode of childbirth delivery, diet, lifestyle habits and use of antibiotics influence the composition of the gut microbiome in the development of obesity is evaluated. Also, the efficacy of current microbiome-based therapies in...
Gut microbes play vital roles in host health and disease. A number of commensal bacteria have been used as vectors for genetic engineering to create living therapeutics. This review highlights recent advances in engineering gut bacteria for the treatment of chronic diseases such as metabolic diseases,...
An imbalance in thegut microbiome- more "bad" bacteria than "good" - is known as dysbiosis, which is caused by environmental stressors, such as intestinal inflammation, antibiotics, or diet. Gut dysbiosis is believed to fuel Crohn's disease and other diseases, but the mechanisms behind that ...
Profiling the Antimalarial Mechanism of Artemisinin by Identifying Crucial Target Proteins 高鹏,王建友,陈嘉鋆,谷丽维,王晨,徐丽婷,Yin Kwan Wong,张会敏,徐承超,戴凌云,王继刚 糖尿病患者在肝脏移植手术后肠道微生物组变化 Alterations in the Gut Microbiome in Li...
Increasing evidence indicates that the gut microbiota can be altered to ameliorate or prevent disease states, and engineering the gut microbiota to therapeutically modulate host metabolism is an emerging goal of microbiome research. In the intestine, bacterial urease converts host-derived urea to ammonia...
Systems Theory-Driven Framework for AI Integration into the Holistic Material Basis Research of Traditional Chinese Medicine 基于系统论框架整合人工智能与中医药整体物质基础研究 曾敬其, 贾晓斌 doi:10.1016/j.eng.2024.04.009 微生态 Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease: Curren...
The incidence of immune disorders is growing parallel with practices associated with westernization, such as dietary changes, increased use of antibiotics, or elevated rates of Cesarean section. These practices can significantly impact the gut microbiota, the collection of bacteria residing in the human...
The role of the gut microbiome in regulating the response to immune checkpoint inhibitor therapy Immune checkpoint inhibitors (ICIs) have revolutionised cancer therapy, yet the proportion of patients who achieve long-term disease control remain subopti... NJ Dean,PD D'Arienzo,H Ibraheim,... - 《...
由山东大学刘双江教授、高翔教授、王明钰教授、刘畅研究员共同担任客座编辑的专刊“Gut Microbiome: A Microbiology Perspective”正在征稿中,投稿截止日期为2025年4月30日。 本专刊以推动对肠道菌群的干预、调控或编辑为最终目的,接收肠道菌群结构与功能、...