Using stochastic simulations, Mobley and Klimovich quantified the effect that this computational prioritization can have on a drug discovery project. They estimate that RBFE calculations with an average of 1.0 kcal mol−1of error to experiment can improve the odds of identifying a tenfold p...
Giovanni Coppola (UCLA) for technical assistance with RNAseq experiments and Dr. Jo Anne Stratton (McGill) for advice on analysis for RNAseq. We thank all lab members for their insightful comments. We thank the developers and distributers of ScanImage open-source control and acquisition software ...