Endosome to lysosome transport is a highly regulated process important for targeting molecules to degradation. Proteins destined to degradation are transported from early endosomes to late endosomes and lysosomes, where degradation takes place. Sorting mechanisms and acidification drive proteins in this ...
Consistent with our discoveries, the inhibition of endosome-to-lysosome transport by either BafA1-inhibited endolysosome acidification59 or silenced RAB7 expression39 enhanced STING activation by increasing STING puncta formation at endosomes. The other group of PI4P-binding proteins relevant for STING ...
In biology, an endosome is a membrane bound compartment inside eukaryotic cells. It is a compartment of the endocytic membrane transport pathway from the plasma membrane to the lysosome. Molecules internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation,...
英['endəsəʊm] 美['endoʊsəm] 是什么意思 n. 内涵体; 英英释义 Endosome In biology, an endosome is a membrane-bounded compartment inside eukaryotic cells. It is a compartment of the endocytic membrane transport pathway from the plasma membrane to the lysosome. ...
Subsequent transport to endosomes occurs via 60–100 nm clathrin-coated vesicles5–7 or pleiomorphic membranes8 that fuse with early endosomes7,9. Considerably less is known about the targeting of lysosomal membrane proteins10. The lysosome-associated membrane proteins (LAMP)-1 and -2 are the ...
complex organelles pivotal in protein and lipid transport that are positioned along the endosome-lysosome pathway, and intersect the exocytic pathway in various... Beatty,L W. - 《Journal of Cell Science》 被引量: 259发表: 2006年 Endosome-lysosome fusion at low temperature. Based on an initial...
(e.g. resident hydrolytic enzymes)6,7. PM proteins destined for the degradative pathway are sorted into intra-lumenal vesicles characteristic of multi-vesicular bodies (MVBs) via the ESCRT system within late endosomes, and are ultimately degraded upon maturation to the lysosome. As such, early/...
Want to thank TFD for its existence?Tell a friend about us, add a link to this page, or visitthe webmaster's page for free fun content. Link to this page: Facebook Twitter Dictionary browser? ▲ endorheic Endorhiza endorhizal endorphin ...
Medical Dictionary for the Health Professions and Nursing © Farlex 2012 Want to thank TFD for its existence?Tell a friend about us, add a link to this page, or visitthe webmaster's page for free fun content. Link to this page: Facebook Twitter...
CORVET and HOPS tethering complexes – coordinators of endosome and lysosome fusion 来自 Semantic Scholar 喜欢 0 阅读量: 168 作者:Balderhaar, H. J. k.,C Ungermann 摘要: Protein and lipid transport along the endolysosomal system of eukaryotic cells depends on multiple fusion and fission events. ...