Endoplasmic Reticulum Stress in Diseases concentrates research findings in this area to allow editorial comments on the prominent articles and grouping of articles with concordant findings. This will emphasize their significance and promote further, more detailed research and thinking in the field. The ...
Endoplasmic reticulum stress Unfolded protein response Hepatosteatosis Liver injury Introduction Described as a response to the accumulation of unfolded proteins in the endoplasmic reticulum (ER), the eponymously named unfolded protein response (UPR) is characterized by the activation of three distinct signa...
ER stress has been implicated in diabetes [8], tyrosinemia [9], cardiovascular diseases [10], viral infection [11], cancer [12], the immune response [13], aging [14], cerebral ischemia [15], neurodegenerative diseases [16, 17], Zα1-antitrypsin deficiency [18], inclusion body myositis ...
The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis, assembly and secretion. Accumulating evidence shows that across several neurodegenerative and neuroprogressive diseases, ER stress ensues, which is accompanied by over-activation of the unfolded protein response (U...
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress, resulting in activation of the unfolded protein response (UPR) that aims to restore protein homeostasis. However, the UPR also plays an important pathological role in many diseases, including metabolic disord...
endoplasmic reticulum stress in disease pathogenesis endoplasmic reticulum stress and cytotoxic signaling from the unfolded protein response Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver diseases in the world. However, its exact mechanism remains unkn... JH...
Endoplasmic reticulum stress in Alzheimer's disease: Molecular mechanisms and therapeutic prospects ? 2023 Elsevier Inc.Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to memory loss and cognitive impairment over time. It ... P Nagar,P Sharma,R Dhapola,... - 《...
Endoplasmic Reticulum Stress in Diseases 来自 De Gruyter 喜欢 0 阅读量: 16 摘要: Why subscribe and readThe journal focuses on the latest insights of the Endoplasmic Reticulum stress role in the physiology, development and progression of relevant human pathological conditions. This is an innovative ...
Endoplasmic reticulum stress (ERS) can trigger various modes of cell death by activating the unfolded protein response (UPR) signaling pathway. Cell death plays a crucial role in the occurrence and development of diseases such as cancer, liver diseases, neurological diseases, and cardiovascular ...
In this review, we summarize the current understanding of the UPR in response to proteotoxic stress and LBS and the breadth of the functions mitigated by the UPR in different tissues and in the context of diseases. Introduction The endoplasmic reticulum (ER) has evolved into an efficient ...