In this sense, the membrane system has an inside and an outside, and ribosomes are bound only to the outside. Cells responsible for secreting large amounts of a particular protein (e.g., hormone-secreting cells) have an extensive endoplasmic reticulum. Most proteins destined to be secreted ...
The endoplasmic reticulum (ER) is a metabolic organelle and an ideal nutrient sensor. In response to hypoglycemia, hyperglycemia or fatty acid overload, the ER triggers the unfolded protein response, which represses protein synthesis, alters insulin responsiveness and favors apoptosis. In addition, ...
ganglioside-induced differentiation-associated protein 1 (GDAP1), originally known to be located on the outer membrane of mitochondria, was found enriched in MAMs. Mutations inGDAP1are linked to CMT, which are either recessive
The membrane and lumen of the endoplasmic reticulum contain proteins that are involved in lipid synthesis, protein synthesis, and processing, as well as ionic regulation. The lipid composition of the endoplasmic reticulum is similar although not identical to the lipid composition of the plasma ...
The endoplasmic reticulum (ER) is a metabolic organelle and an ideal nutrient sensor. In response to hypoglycemia, hyperglycemia or fatty acid overload, the ER triggers the unfolded protein response, which represses protein synthesis, alters insulin responsiveness and favors apoptosis. In addition, th...
The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated degradation, protein chaperons, and autophagy. ER stress is activated when proteostasis is broken with an accumulation of misfold...
Three ER membrane sensors activating transcription factor 6 α (ATF6α), inositol requiring (IRE) 1α, and PKR-like ER-localized kinase (PERK) mediate signals from the endoplasmic reticulum (ER) upon activation of the unfolded protein response (UPR). The accumulation of misfolded proteins in th...
Endoplasmic Reticulum Theendoplasmic reticulum(ER) exists in the cell in two forms, thesmoothER(SER) and therough ER(RER). It is a network of interconnected membrane-bound and flattened sacs throughout the cell cytoplasm. The RER is similar to the SER except that the RER displaysribosomesattac...
Support for this was provided by the findings that ER membrane reorganization was induced by agents that either deplete ER Ca(2+) (thapsigargin) or cause an alteration in cellular Ca(2+) handling (calmodulin antagonists). Furthermore, overexpression of the ER luminal Ca(2+) sensor, STIM1, ...
The endoplasmic reticulum: a sensor of cellular stress that modulates immune responses 来自 国家科技图书文献中心 喜欢 0 阅读量: 46 作者: F Martinon 摘要: Many inflammatory and infectious diseases are characterized by the activation of signaling pathways steaming from the endoplasmic reticulum (ER). ...