Endoplasmic reticulumGlycoproteinThe gene manE, encoding a probable class I endoplasmic reticulum1,2-伪-mannosidases (ER-Man), was identified from the filamentous fungus Aspergillus oryzae due to similarity to orthologs. It removes a single mannose residue from MangGlcNAc_2, generating Man_8GlcNAc_2...
Endoplasmic reticulum An intracellular membrane system that is present in all eukaryotic cells. In most cells the endoplasmic reticulum is thought to consist of only one continuous membrane enclosing only a single space. However, in protozoa, some unicellular algae, and possibly some fungi, the endop...
The designation arises from the morphology observed in the electron microscope images of the endoplasmic reticulum. Some parts of the endoplasmic reticulum have bumps, giving it a rough appearance. The bumps are ribosomes. One class of ribosomes is membrane bound and they bind to the endoplasmic ...
Here, we investigated the role of Arabidopsis thaliana class I ±-mannosidases (MNS1 to MNS5) in glycan-dependent ERAD. Our genetic and biochemical data show that the two ER-resident proteins MNS4 and MNS5 are involved in the degradation of misfolded variants of the heavily glycosylated ...
Structure of Penicillium citrinum alpha 1,2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and Golgi class I enzymes. J Biol Chem 277: 5620-5630.Lobsanov YD, Vallee F, Imberty A, Yoshida T, Yip P, Herscovics A, Howell PL (2002) Structure of ...
Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP. Golgi-situated endoplasmic reticulum alpha-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with gamma-COP. ...
Z. Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5–6GlcNAc2 in glycoprotein ER-associated degradation. Mol. Biol. Cell 19, 216–225 (2008). CAS PubMed PubMed Central Google Scholar Hosokawa, N. et al. Enhancement of endoplasmic ...
c Activating transcription factor 4 (Atf4), Heat Shock Protein Family A (Hsp70) Member 5 (Hspa5) and ER Degradation Enhancing Alpha-Mannosidase Like Protein 1 (Edem1) soleus muscle UPR gene expression in Het CerS2 H/A (grey) and Homo CerS2 H/A (blue) mice compared to WT (red) (WT...
Though ATF6α can bind some of these elements as well, sXBP1 homodimers and sXBP1-ATF6 heterodimers bind to ERSE activating the transcription of several XBP1 target genes, including Herp [151], EDEM (ER degradation-enhancing alpha-mannosidase-like protein) [155], and MDG1/ERdj4 [62]. ...
There is an important role for an ER-resident mannosidase, ER degradation-enhancing alpha-mannosidase-like protein 1 (EDEM-1). In addition, members of the heat shock protein (HSP) family, such as Bip and Gp96, together with their J-domain containing co-chaperones, have been implicated in ...