Endometrial cancer (EC) is the fourth most common cancer among women worldwide. Unlike those of other cancers, its incidence rate and mortality are increasing [1,2]. By 2040, it is expected to surpass colorectal cancer and become the third most common cancer and fourth leading cause of cance...
The aim of this retrospective study was to assess the correlation betweenMMR status, disease recurrence patterns, and RFS in patients with HIR endometrioid endometrial cancer (EEC). The study was performed at a single institution between 2007 and 2016. A chart review for consecutive patients ...
release, has seldom been studied in tumor progression, but studies show its high expression in lung adenocarcinoma is linked to poor prognosis39. EYA2, a member of the eyes absent protein family, promotes cancer progression by inducing TGF-β, epithelial-mesenchymal transition in cancer cells, or...
The complex interplay between Sirtuin 1 (SIRT1) and FOXO3 in endometrial cancer (EC) remains understudied. This research aims to unravel the interactions of deacetylase SIRT1 and transcription factor FOXO3 in EC, focusing on their impact on mitophagy and hormone resistance. Methods High-throughput ...
patients (n = 101) had histologically conf i rmed endometrial cancer and were treatedwith bevacizumab at our institution from 2004 to 2017. Demographic data and tumor characteristics were ob-tained through chart review. Primary objective was response to therapy determined by Response EvaluationCriteria...
fertility, or are poor surgical candidates, but there is a paucity of clinical trail data on the subject. High dose progestin therapy can succeed in ablating some EIN lesions, but, because of the high concurrent cancer rate and unpredictable response, must be accom...
ARID1A mutations are also observed in atypical endometrial hyperplasia (Mao et al., 2013; Werner et al., 2013) and endometrial cancer (Guan et al., 2011; Wiegand et al., 2011). Endometriosis is characterized by the growth and spread of abnormal endometrial tissue at sites outside of the ...
The rates of severe or Class III obesity (BMI ≥ 40.0 kg/m2) and endometrial cancer (EC) incidence and mortality have been increasing significantly in the United States. Adults with severe obesity are more likely to die and women with severe obesity have a higher risk of EC developm...
shuttles to the nucleus, dimerizes with HIF-1b and initiates transcription of specific genes involved in glycolysis, angiogenesis and oxygen homeostasis.7 HIF-1 induces the expression of glycolytic enzymes and glucose transporters, enabling thereby cancer cell survival by controlling sufficient ATP product...
The main line of management is a total abdominal hysterectomy and bilateral sapling-oophorectomy and if diagnosed early, the five-year survival rate in the low-grade tumors is greater than 90 percent. In this case report, we present a case of low-grade endometrial sarcoma which was initially...