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Bone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing number of studies have characterized the significance of bone as an endocrine organ, suggesting that bone-derived factors regulate loca...
Histone modification involves altering the chromatin structure; it also takes a part in the regulation of gene expression [36]. Lastly, noncoding RNAs are involved in chromatin function and can modulate gene expression with gene silencing. Known EDCs that affect male and female reproduction include ...
In primary hyperfunction of anendocrine gland, cells (often neoplastic and derived from the gland) synthesize and secrete hormone at an autonomous rate in excess of the body's ability to use and subsequently degrade the hormone, thereby resulting infunctional disturbances of hormone excess. These i...
In general, each of the NRs maintained a common structure with a ligand-binding domain (LBD) to bind to the hormone and a DNA-binding domain to activate transcription. While the percentage of sequence identity for a given receptor can vary from 60 to 70% between human and fish (Thornton,...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients. J Nutr Health Aging. 2006;10:377–85. CAS PubMed Google Scholar Grandjean P, Landrigan PJ. Developmental neurotoxicity of industrial chemicals....
In menopause, there is a natural decline in estrogen levels, which increases the risk of osteoporosis, characterized by low BMD and deterioration of the architectural structure of the bones.18 This is the main reason why up to 50% of women are likely to have a fracture after the age of ...
Two groups comparison (Mann-Whitney-U test) was conducted for the parental F0 HAB and LAB mice to examine differences in the endocrine stress measures. A principal component (PC) analysis was applied to examine the phenotypic structure of the F2 mice. PC analysis was used to reveal the phenot...
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