Among the two antibiotics recommended for VRE severe infections in the 2015 AHA/IDSA infective endocarditis guidelines, daptomycin and linezolid, there is ongoing debate about the merits of both due to concerns about perceived mortality differences, adverse drug reactions, and proper dosing. Given the...
Goals to maximize treatment success are early diagnosis, accurate microorganism identification, reliable susceptibility testing, prolonged intravenous (IV) administration of bactericidal antimicrobial agents, proper monitoring of potentially toxic antimicrobial regimens, and aggressive surgical management of correctabl...
The IDSA guidelines for treatment and diagnosis of native vertebral osteomyelitis states that efforts should be made to exclude contamination when a common skin contaminant, eg CoNS, is isolated [18]. In patients with sustained CoNS bloodstream infection and an intravascular device or prosthetic valve...
No current diagnostic and therapeutic guidelines are available to treat IE caused by these organisms. Based on a case report, we provide a review of the literature of IE caused by L. garvieae and highlight diagnostic and treatment challenges of these infections and implications for management. ...
In the case report it appears that daptomycin was initially underdosed for bacteraemia treatment according to the FDA summary product characteristics (6 mg/kg/48 h) and also according to expert opinion (8鈥 10 mg/kg) as mentioned in the IDSA guidelines. Linezolid, a bacteriostatic agent non-...
We could not demonstrate a significant survival benefit of combined medical-surgical therapy compared to deliberate medical treatment in patients with a low to moderate propensity for surgery according to treatment guidelines. There remains a role for watchful waiting with antimicrobials only in this ...