Granulomas were not identified in 2 lungs in the fibrotic phase. In contrast to the honeycombing of UIP, the honeycombing was predominantly central, with prominent bronchiectasis. These end-stage sarcoid lungs were characterized by a fibrotic and active granulomatous pattern, both of which are ...
Research question to investigate the role of the (small) airways in fibrotic sarcoidosis. Study design and methods: Airway morphology was investigated in 7 explant lungs with end-stage fibrotic sarcoidosis using a combination of CT (large airways), microCT (small airways) and histology and ...
Following the migration of lymphoid precursors to the thymus, four stages of double-negative development lead to a double positive thymocyte. Loss of signalling components Lck, SLP-76, and LAT-1 results in a block at this stage of T cell development. Exposure to self-antigens presented by ...
These patients were predominantly men and carried the diagnosis of sarcoidosis on average of 4.2 (3 -7) yrs. Histopathologic examination revealed moderate to severe chronic interstitial pneumonitis previously described as atypical in end-stage sarcoidosis. Furthermore, 3 of these patients had a pattern...