The above-described glyoxalase system catalyzes the biotransformation of methylglyoxal to D-lactate (4.11), which in turn is converted into pyruvate (4.12) by D-lactate dehydrogenase. Aldose reductase (ALR2, AKR1B1) catalyzes the NADPH-dependent reduction of methylglyoxal into lactaldehyde (4.13) ...
In presence of 0.5 mM AMP, the decarboxylation reaction was inhibited up to 50% of the control while even in presence of 5 mM AMP, the carboxylation reaction was unaffected (Fig. 3). Lombricine phosphate, one of the naturally occurring phosphagens in Tubifex , activates the PEPCK-catalyzed...