Astrocytes extend endfeet that enwrap the vasculature, and disruptions to this association which may occur in disease coincide with breaches in blood-brain barrier (BBB) integrity. Here we investigate if focal ablation of astrocytes is sufficient to disr
The approach to nutrition support at the end of life may differ based on where the patient is dying. As the name suggests, an intensive care unit (ICU) is a location where intense medical and surgical treatment is provided. Despite the lifesaving therapy that occurs in the ICU, many deaths...
explores nomenclature, the introduction of the concept of death, relevant historical studies, limitations to the shared decision-making model, the current state of end of life autonomy in pediatrics, and future directions and needs. Although progress is being made toward a more uniform and ...
Keywords: end of life; pediatrics; palliative care; shared decision-making 1. Introduction A natural response in medical decision-making for a pediatric patient is to delegate authority to the supervising parent or caregiver. This frequently occurs while providing families with the specifics of ...