Enantiospecific analysis of chiral POPs is important, since enantiomers of chiral compounds often exhibit differences in biological activity, and most biochemical processes in nature are stereospecific. The effects and the environmental fate of the enantiomers of chiral pollutants therefore need to be ...
To derivatize amino acid compounds, the product was dissolved in 500 μl of DI water, and then 50 μl of an aqueous solution was mixed with 20 μl of 200 mM sodium bicarbonate and 20 μl of 1% L-FDLA in acetone. The mixture was incubated at 37 oC for 30 min. ...
In our present study, eight pairs of enantiomers (1a/1b–8a/8b, Fig. 1), including a pair of enantiomeric neolignans (1a/1b), two pairs of norlignans (2a/2b and 3a/3b) and five pairs of sesquilignans (4a/4b–8a/8b), along with five known compounds (9a/9b, 10, 11 and 12) ...
Additionally, these compounds were found to decrease the expression of sphingosine kinase 1 (Sphk1) in MCF-7 cells. Notably, compounds4aand5bexhibited IC50values of 7.45 and 8.97μM, respectively, in MCF-7 cells.Springer Nature SingaporeNatural Products and BioprospectingShuang-Shuang Xiehttps://...
This result shows how important the nature of the substituent is for the crystal packing. The differences in crystal packing have been related to differences in melting enthalpy and entropy between the racemic and enantiomeric acids. In a comparison with the equivalent 2-(4-chlorophenoxy)-propionic...
Excellent separations were achieved for most of these compounds in the reversed phase mode. Both the nature of the stationary phase and the composition of the mobile phase strongly influenced enantiomeric resolution. The best results were obtained using diphenyl stationary phases. Acetonitrile was the ...
compounds, suggesting they shared the same planar structure. Obvious differences between both alkaloids were the highfield signals of C-1 (δC34.5,ΔδC− 2.3), C-2 (δC74.6,ΔδC− 1.6) and C-3 (δC79.1,ΔδC− 3.9) in2, indicatingα-configuration of H-2 in2as in cephalo...
In 1848,1 Pasteur kick-started the field of stereochemistry when he reported that crystallization of racemic compounds can afford spontaneous resolution (racemic conglomerates), but this remains the exception rather than the norm. Today, enantiomeric separation and identification matters to technologies as...
Nature Protocols volume 15, pages 2203–2229 (2020)Cite this article 2385 Accesses 5 Altmetric Metrics details Abstract Determining enantiomeric excess (e.e.) in chiral compounds is key to development of chiral catalyst auxiliaries and chiral drugs. Here we describe a sensitive and robust fluores...
Presence of terrestrial magnetic field can in principle break the chiral symmetry of biomolecules. In an effect labeled “magnetochiral dichroism”, unpolarized light propagating in the direction of a magnetic field can produce an EE in some chemical reactions involving metal and organic compounds8. ...