RouteOnsetPeakDuration PO1 hr4-6 hr24 hr IV15 min1-4 hr6 hr Readily absorbed from the GI tract (not affected by food).Protein binding: 50%-60%. Converted toactive metabolite. Primarily excreted in urine. Removed byhemodialysis.Half-life:11 hr (half-life is increased in those with imp...
In short-term hemodynamic studies, the onset of action and peak effect are earlier with captopril. Enalapril has a much more gradual onset and longer duration of action. Both drugs have a shallow dose-response curve and both produce comparable hormonal changes: an increase in plasma renin ...