Maximum dose: 40 mg orally daily as a single dose or in 2 divided doses In combination with diuretics: Initial dose: 2.5 mg orally once a day If feasible, the diuretic should be discontinued 2 to 3 days prior to initiation of therapy with enalapril. If required, diuretic therapy may be...
These doses are 26 times (in rats and female mice) and 13 times (in male mice) the maximum recommended human daily dose (MRHDD) when compared on a body surface area basis. Neither enalapril maleate nor the active diacid was mutagenic in the Ames microbial mutagen test with or without ...
The dose may be increased after 2-3 weeks if adequate. The maximum dose is 2 tablets of 10/25 mg/mg once daily. Is enalapril and hydrochlorothiazide safe to take if I'm pregnant or breastfeeding? ACE inhibitors, including enalapril, should be avoided in nursing mothers. What else should ...
The maximum recorded fall in meanarterial blood pressurewas significantly greater than placebo (–16 ± 7.7 mmHg) forCaptopril(−22 ± 12) and enalapril (−26 ± 8) but not perindopril (–15 ± 8). Enalapril reduced the heart rate (–11 ± 7 beats/min) compared to placebo (4–8 ...
90 mg/kg/day or for 94 weeks to male and female mice at doses up to 90 and 180 mg/kg/day, respectively. These doses are 26 times (in rats and female mice) and 13 times (in male mice) the maximum recommended human daily dose (MRHDD) when compared on a body surface area basis...
daily given as a single dose or in two divided doses; or 1.25 mg I.V. q 6 hours. For patients taking diuretics-initially, 2.5 mg P.O. or 0.625 mg I.V. Children: 0.08 mg/kg P.O. once daily; may be increased based on blood pressure response up to 5 mg daily. Maximum dosage ...
Patients who did not achieve a supine diastolic blood pressure of less than 90 mm Hg after six weeks of enalapril (maximum dose = 40 mg/d) or metoprolol (maximum dose = 400 mg/d) had hydrochlorothiazide 50 mg/d added to their treatment regimen for an additional six weeks. Both ...
After a placebo run-in period the patients received increasing dosages of medication every 2 weeks until the target diastolic blood pressure of 90 mm Hg or less was achieved on two consecutive visits, the maximum dosage was reached, or the patient withdrew because of adverse effects. At 14 ...
The reduction of angiotensin II leads to peripheral vasodilatation and reduced vascular resistance, decreasing blood pressure values.21,39,40 Enalapril is a dose- dependent antihypertensive drug, with its maximum effect occurring 6–8 hours after administration and a total duration of effect of 24...
Conditional on diastolic pressure, the dose was increased at 4‐wk intervals to a maximum of 40 mg daily or until control was achieved or the end of the study reached. At the end of the 12‐wk titration phase, there was a follow‐up period during which measurements were made after ...