Enalapril (10 mg/day) in systemic sclerosis. One year, double blind, randomised study (ESS-1): pulmonary substudy--effects of three month treatment.HumansScleroderma, SystemicEnalaprilRespiratory Function TestsAngiotensin-Converting Enzyme InhibitorsDouble-Blind Method...
10. Overdosage Limited data are available in regard to overdosage in humans. Single oral doses of enalapril above 1,000 mg/kg and ≥1,775 mg/kg were associated with lethality in mice and rats, respectively. The most likely manifestation of overdosage would be hypotension, for which the us...
Hypertension alone or in combination with otherCV-antihypertensive-ACEs: PO Initially, 2.5-5 mg/day. May increase at 1-2 wk intervals. Range: 10-40 mg/day in 1-2 divided doses. IV 0.625-1.25 mg q6h up to 5 mg q6h. Adjunctive therapy forCHF: PO Initially, 2.5-5 mg/day. Range: ...
A cohort of 450 patients with essential hypertension taking 10 mg enalapril maleate were genotyped for the functional SLCO1B1 variants, 388A > G (Asn130Asp, rs2306283) and 521T > C (Val174Ala, rs4149056). The primary endpoint was cough, which was recorded when participants ...
HumansReninEnalaprilBlood PressureHeart RateHypertensionAdultAgedHemodynamicsPeptidyl-Dipeptidase AThe purpose of this study was to assess the effect of a daily low dose of the angiotensin-converting enzyme (ACE) inhibitors, captopril or enalapril, in mild essential hypertension. Nine men with seated ...
Article: Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapri
2 Absorption of enalapril maleate (10 mg, p.o.) was rapid, with peak serum concentrations of enalapril observed 0.5-1.5 h after administration. Based upon urinary recovery of total drug (enalapril plus MK-422), absorption was at least 61%. Bioactivation appeared to be largely post-absorptive...
Recent studies in diabetic humans have shown that angiotensin converting enzyme (ACE) inhibitors may provide additional renal benefit above and beyond conventional antihypertensive agents. We investigated the effect of enalapril on urinary glycosaminoglycans (GAG), heparan sulphate (HS) and microalbuminuria ...
HumansAsthmaHypertensionSubstance PEnalaprilBronchial Provocation TestsMiddle AgedFemaleMaleThe subjects, six asthmatic patients with mild essential hypertension, were aged 48 to 63 years and each was being treated with theophylline. Five patients received 10 mg of enalapril daily for two weeks and one ...
HumansHypertensionEnalaprilEnalaprilatAntihypertensive AgentsAnalysis of VarianceArea Under CurveConfidence IntervalsAdolescentChildForty children with hypertension between the age of 2 months and 15 years received 0.07 to 0.14 mg/kg of enalapril as a single daily dose. Enalapril was administered orally as a...