In anaesthetized dogs, i.v. administration of the NO synthase (NOS) inhibitor NG-nitro-l-arginine methyl ester (l-NAME; 0.1-10 mg/kg) significantly elevated arterial blood pressure, with concomitant bradycardia. The compound NCX899 significantly attenuated both arterial hypertension and bradycardia,...
The pharmacodynamics of enalapril have been examined in experimental dogs. A dose of 0.3 mg/kg administered per os results in approximately 75% inhibition of the pressor response to angiotensin I. This effect lasts for at least 6 h and is completely dissipated by 24 h after administration. A ...
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Methods: CHF was produced in 20 dogs by rapid right ventricular pacing during 5 weeks. The dogs were randomized to enalapril (EN) therapy (2 mg/kg/day, n=10) or to a control group (n=10). Echocardiography was performed at baseline and weekly thereafter. At the 5-week ...
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It is being explored as adjunctive treatment in chronic renal failure and protein losing nephropathies. While ACE inhibitors are a mainstay for treating hypertension in humans, they have not been particularly useful in treating hypertension in dogs or cats. View all ...
The dogs were randomized to enalapril (EN) therapy (2 mg/kg/day,n=10) or to a control group (n=10). Echocardiography was performed at baseline and weekly thereafter. At the 5-week electrophysiological study, AF was induced by burst pacing and AF duration was measured.Results:Atrial areas...
Peak levels of radioactivity in plasma occurred in 30 min in rats and 2 hr in dogs after a single dose of 14C-enalapril maleate (1 mg/kg, po). Rats excreted 26% of the dose in the urine and 72% in the feces in 72 hr; dogs excreted 40% of the dose in the urine and 36% in...