Cre重组酶在雄性生殖细胞中也有表达。Emx1-Cre;floxed双突变雄性与floxed雌性交配产生了一些带有floxed等位基因生殖系缺失的后代。 5.研究应用 研究方向及表型: 工具鼠(前脑发育和功能的研究) 具体内容及相关参考文献: 将Emx1-cre与R26R品系杂交,cre介导的重组会导致侧翼序列的组织特异性缺失。重组发生在大约88%的新...
将IRES-Cre插入到小鼠Emx1基因终止密码子处。 应用领域:Cre工具,88%的大脑皮层和海马神经元,大脑皮质神经胶质细胞等区域 *使用本品系发表的文献需注明: Emx1-IRES-Cre mice (Cat. NO. NM-KI-200149) were purchased from Shanghai Model Organisms Center, Inc.. ...
88 p. 网络访问控制的语义相容性快速分析技术研究与实现 64 p. 石墨烯及金属氧化物石墨烯复合材料的制备及其在生物传感器中的应用 69 p. 深度学习在药物虚拟筛选大规模化合物数据库中的应用 59 p. 面向影音业务的移动宽带通信节带化技术研究 63 p. 螺纹联接自动拆装柔性机械手控制系统研究 129 p. 近...
( 2011 ) Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice . Neurochem. Res. 36 , 1293 – 1303 .He X, Takahashi S, Suzuki H, Hashikawa T, Kulkarni AB, Mikoshiba K, Ohshima T: Hypomyelination phenotype caused ...
在本研究中发现,Emx1-Cre,D6-Cre,hGFAP-Cre工具鼠Cre重组酶在大脑皮层中的起始表达时间分别为胚胎期第9.5天(即E9.5),E10.5以后(约为E11)和E12.5.随着发育的进行,D6-Cre重组酶的表达始终局限于端脑,而Emx1-Cre和hGFAP-Cre的表达范围在不断扩大.同时,在利用不同Cre工具鼠条件性敲除Dicer时均出现了神经元...
In the present study, the specificity and efficiency of the cre-mediated recombination were determined using three independent lines of reporter mice and a combination of histochemical staining, neuronal culture, and Southern detection of the genomic DNA. Our results showed that the recombination was ...
图1:荧光检测 Emx1-Cre; R26-tdTomato小鼠大脑中tdTomato的表达情况。 A. Scale bar=200μm B. Scale bar=100μm C. Scale bar=10μm Hippo: Hippocampus; Sn: Substantia nigra. 相关品系 Emx1-KO 品系名:C57BL/6Smoc-Emx1em1Smoc 品系状态:胚胎冻存 | 目录号:NM-KO-2101094 ...
In this study, we performed chemogenetic inhibition within the ventral dentate gyrus (vDG) of mice with IRSp53 deletion in Emx1-expressing cells (Emx1-Cre;IRSp53 flox/flox). We observed the recovery of social deficits after chemogenetic inhibition within vDG of Emx1-Cre;IRSp53 flox/flox ...
Disclosed herein are an α 1/CaV3.1 double knockout mouse or α 1;Emx1-Cre mouse with enhanced essential tremor and a screening method of therapeutic agents for essential tremor by using the same. The α 1/CaV3.1 double knockout mouse or α 1;Emx1-Cre mouse of the present invention ...
Hypomyelination Phenotype Caused by Impaired Differentiation of Oligodendrocytes in Emx1-cre Mediated Cdk5 Conditional Knockout Mice Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in neuronal migration and differentiation, and in axonal elongation. Although many studies have been ... X He,S ...