5、段 上皮层卷曲形成原始消化管基底的一小部分细胞变松散,从基底膜脱离,爬行进入囊胚腔脊索动物的神经胚形成脊索动物的神经胚形成组织中的组织中的EMTuEpithelium I induces an EMT process in epithelium II (black arrows) through the secretion of inducers (purple dots). The epithelium II-derived mesenchymal...
参考文献: Li Y, Shen Z, Jiang X, Wang Y, Yang Z, Mao Y, Wu Z, Li G, Chen H. Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT/GSK3β pathway via c-MET in radiation-induced lung injury. J Exp Clin Cancer Res. 2022 Apr 7;41(...
code repo for some data processing scripts. Contribute to emt-project/emt-process development by creating an account on GitHub.
Transition(EMT)病理学系林琛莅igene@yahoo.cn EMT的定义 上皮细胞在形态学上发生向间(充)质细胞表型的转变并获得迁移的能力。EMT是胚胎发育中的一个基本过程,它使在特殊部位产生的上皮细胞从上皮组织分离并迁移到其他位置,是正常发育、伤口愈合以及恶性上皮肿瘤发生的基础。细胞的分类 上皮细胞间(充)质细胞...
结论:TAN 能够促进EC 细胞EMT 进程并增强细胞自噬,使用自噬抑制剂3MA 干预后,TAN 诱导的EC 细胞EMT 与自噬均受到抑制。[关键词] 子宫内膜癌;肿瘤相关中性粒细胞;上皮-间质转化;自噬Effects of tumor -associated neutrophils on EMT process and autophagy in human endometrial cancer cells FANG Qiuman ...
Moreover, miRNAs have also been described to regulate the EMT process. One example is the miRNA-200 family, which targets the transcriptional repressors (for example, ZEB1 and ZEB2) of E-cadherin and blocks the invasion of cancer cells.8 However, to the best of our knowledge, miRNAs that ...
we evaluated the changes in the EMT process. At first, IF staining revealed that the intensity of E-cadherin was reduced under LPS treatment, whereas that of Vimentin was enhanced (Fig.S1C). Subsequently, we assessed the levels of EMT markers with RT-qPCR and western blot assay. According ...
In addition, LINC01857 could increase the activity of PI3K/mTOR pathway and facilitate the EMT process in a miR-141-3p-mediated manner in DLBCL. Our data illustrated that the LINC01857/miR-141-3p/MAP4K4 might function as a promising therapeutic avenue for DLBCL treatment. 展开 ...
Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-differentiation where cancer cells transit between various stages of an EMTcontinuum, including epithelial, partial EMT, and mesenchymal cell states. We have employed Tamoxifen-inducible dual recombinase lineage tracing ...
SCH79797 could reverse the positive impact of KLK8 on the EMT process in CRC both in vitro and in vivo. Taken together, these findings demonstrated for the first time that KLK8 promoted EMT and CRC progression, and this effect might be, at least partly mediated by PAR1-dependent pathway....