In a process of epithelial-mesenchymal transition (EMT), besides changing their adhesive repertoire, cancer cells employ developmental processes to gain migratory and invasive properties that involve a dramatic reorganization of the actin cytoskeleton and the concomitant formation of membrane protrusions ...
3 .月中瘤干细胞(cancer stem cell CSC)学说:月中瘤组织或者月中瘤转移灶中存在极 少的且具有无限自我更新能力并可导致月中瘤发生的细胞一月中瘤干细胞,CSC皆月中瘤发生、复发和转移的密切相关。第二节:上皮间质转化与肿瘤干细胞与恶性肿瘤生物学行为1 上皮间质转化(EMT )与肿瘤恶性生物学行为1.1 上皮间质...
3. Zheng X, Carstens JL, Kim J, et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 2015. doi: 10.1038/nature16064. 4. Pastushenko I, Brisebarre A, Sifrim A,...
参考文献 Viswanathan VS, Ryan MJ, Dhruv HD, et al.Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.Nature. 2017 Jul 27;547(7664):453-457. (doi: 10.1038/nature23007) 福利:19.9元购买权益。(原价99元) 如果想看全部的文献精读课,可以扫下面的二维码购买课程录...
近日,Oncogene期刊在线发表了中国医学科学院医药生物技术研究所王真研究员团队的研究成果FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation。该研究发现,F-box家族蛋白FBXO28可结合SNAI2并...
[15] Zhou, et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition. Nat Cell Biol. 2004, 6: 931-940. [16] Kaler P, et al. Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk inter...
Epithelial cancers make up the vast majority of cancer types and, during the transition from benign adenoma to malignant carcinoma and metastasis, epithelial tumor cells acquire a de-differentiated, migratory and invasive behavior. This process of epithelial–mesenchymal transition (EMT) goes along with...
whereas full EMT cells mostly retain a mesenchymal phenotype and fail to colonize the lungs. However, full EMT cancer cells are enriched in recurrent tumors upon chemotherapy. Hence, cancer cells in various stages of the EMT continuum differentially contribute to hallmarks of breast cancer malignancy...
Mechanistically, HDAC2 promotes epithelial﹎esenchymal transition (EMT) in colorectal cancer cells by combining HDAC1 with EZH2 (a key histone methyltransferase), possibly through the modular scaffold function of a new lncRNA, ENSG00000274093.1. HDAC2 thus appears to promote CRC cell migration and ...
今天分享的是 2019 年 3 月发表在 molecular cancer 的一篇文章,影响因子为 27.401。 首先,我们根据题目和摘要提取科学要素,做出科学假设。 题目:Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT 【题目四要素】疾病:肺癌 ...