近日,Oncogene期刊在线发表了中国医学科学院医药生物技术研究所王真研究员团队的研究成果FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation。该研究发现,F-box家族蛋白FBXO28可结合SNAI2并...
3. Zheng X, Carstens JL, Kim J, et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 2015. doi: 10.1038/nature16064. 4. Pastushenko I, Brisebarre A, Sifrim A,...
In mouse RAW264.7 macrophages and bladder cancer MB49 cells, siRNA technology was used to knockdown the expression of TNF-伪 in RAW264.7 cells. Western blot assay was performed to detect the levels of related protein expression of EMT in MB49 cells, while immunofluorescence assay was used to ...
Viswanathan VS, Ryan MJ, Dhruv HD, et al.Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.Nature. 2017 Jul 27;547(7664):453-457. (doi: 10.1038/nature23007) 来自:
Nat Cell Biol. 2004, 6: 931-940. [16] Kaler P, et al. Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. Oncogene. 2009 Nov 5, 28(44): 3892-3902. [17] Long X, et al. MRGBP promotes colorectal cancer ...
Cells undergoing partial EMT contribute to lung metastasis and chemoresistance, whereas full EMT cells mostly retain a mesenchymal phenotype and fail to colonize the lungs. However, full EMT cancer cells are enriched in recurrent tumors upon chemotherapy. Hence, cancer cells in various stages of the...
Targeting of alpha(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia (New York, NY) 2011; 13(6): 516-25.6.van den Brink GR, Bleuming SA, Hardwick JC, et al. Indian Hedgehog is an antagonist of Wnt signaling ...
Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. Oncogene. 2009 Nov 5, 28(44): 3892-3902. [17] Long X, et al. MRGBP promotes colorectal cancer metastasis via DKK1/Wnt/β-catenin and NF-kB/p65 pathways mediated...
Our knowledge in the field of cancer stem cell biology is progressively increasing. Recently, it has been demonstrated that CSCs can arise from differentiated, non-tumorigenic tumor cells lacking self-renewal properties through Epithelial to Mesenchymal Transition (EMT). In fact, this trans-...
all #文章中给的信息 #tumour cells (expressing EpCAM, PGR and TFF3—all markers of ECs21), #immune cells (marked by CD45+(PTPRC) expression), #cancer-associated fibroblasts (CAFs, marked by αSMA+(ACTA2)) and #endothelial cells (PECAM1 positive) library(ggplot2) genes_to_check = c(...