Discover resources for your Pearson Brady EMT courses, including digital tools, key titles and peer research.
71,72,73]. The presence of activin A in subepicardial tissue has already been reported [74], and more recently, a single-cell RNA sequencing (scRNA-seq) dataset of the embryonic mouse epicardium revealed ALK4 mRNA expression in a subset of epicardial...
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This is an engineering compromise, as having more binders duplicates some easy theor- ems but, in exchange, they simplify the harder theorems that rely on facts about LN open/close operations. Other compromises are possible. This concludes the technical development, and represents a full proof of...
Full size image When TGF-β signaling was blocked by SD-208, an effective inhibitor of TGF-β receptor I, subcutaneous tumor growth was promoted (DU 145 cells, Supplementary Fig. 1a–c) or unaffected (PC-3 cells, Supplementary Fig. 1d–f), while tibial tumor growth was suppressed in both...
Initial reports suggested EMT to be coupled with a gain of stemness [151,152]; however, more recent studies have shown that full EMT might reduce tumor initiation potential of cancer cells [39,40,77,78]. Instead, stemness is most likely maintained by cells in hybrid E/M state rather tha...
Full size image Fig. 2: Interactions between p53 and MDM2 in respect to EMT-TFs Twist, Snail, and Slug, which are mediated by miRNAs and lncRNAs in breast cancer. The color-coding is the same as in Fig.1. Full size image The importance of p53 in averting cancer metastasis is evident ...
Full size image Discussion Recent studies have found that the choroidal structure and function of diabetic patients change before the development of DR [12,13]. A high glucose environment induces the formation of CNV in the body and CNV causes subretinal fibrosis in the late stage [14,15]. Fi...
Drug Design, Development and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Ecust004 Suppresses Breast Cancer Cell Growth, Invasion, and Migration via EMT Regulation Ziyu Liu1,2 Leilei Huang3,4 Liwei Sun1 Hui Nie3,4 Yuqi Liang1,...
Shown are the mean fold changes in 3D MSCs relative to 2D MSCs, as determined by qPCR with normalization to GAPDH levels (mean ± SEM, three experiments; n = 6; *p < 0.05). Full size image To further examine the dynamic chromatin remodeling of 3D MSCs, we next examined ...