GSEA was run using the log2 ratio of classes metric, the weighted scoring scheme, the gene set permutation mode, 1000 gene set permutations, and the GSEA mouse gene symbol to human ortholog file v7.5.1. Heatmap generation MiRs were filtered by a padj < 0.05 when comparing 5% vs 0.1% ...
Post-transcriptional modifications of RNA constitute an emerging regulatory layer of gene expression. The demethylase fat mass- and obesity-associated protein (FTO), an eraser of N6-methyladenosine (m6A), has been shown to play a role in cancer, but its