Cancer cell plasticityEMTMetastasisPartial-EMTTumor-initiating cells (TICs)Carcinoma cells that are induced to suppress their epithelial features and upregulate mesenchymal gene expression programs acquire traits that promote an invasive and metastatic phenotype. This is achieved through the expression of a ...
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of stem cell-directed tumor therapies, there is a need to understand interrelationships between stem cell, epithelial–mesenchymal, and tumor-associated reprogramming events to develop new therapies that mitigate cell state plasticity and minimize the evolution of tumor heterogeneity....
The changes in the expression level of E-cadherin are closely associated with enhanced EMT and metastasis. Snail1 is also able to regulate the proteins involved in cell-cell interaction and cell structures such as Claudin (CLDN), Occludin (OCLN), Zona occludens 1 (ZO-1), Cytokeratin 18, ...
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