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2015) [103], was found to be reduced and discontinuous among epicardial cell clusters in regions of active EMT, suggesting the presence of a disrupted basement membrane that may facilitate EPC migration; likewise, integrin α4 was significantly downregulated in regions exhibiting heightened EMT [104...
104 103 102 0 0 103 104 105 CD38 * ** *** MCF7 CTRL MCF7 MLR MCF7 MIX 105 104 103 3,06 102 0 0 103 104 105 CD38 100 80 Live cells Annexin V+ cells 400 350 ** HepG2 CTRL HepG2 MLR 105 60 Annexin V+ PI+ cells 300 250 * HepG2 MIX 104 40 100 103 20 50 102 0...
另外,在肿瘤边缘具有强大侵袭能力的细胞群里发现,高表达的β-catenin不仅调节细胞EMT相关的转移侵袭蛋白,而且还能够影响细胞中某些干细胞分子标记物(hTert和survivin)的表达[104]。当然,其他一些研究资料也提示,完成EMT转化的瘤体中通常有丰富的CSC存在[53-55]。
code repo for some data processing scripts. Contribute to emt-project/emt-process development by creating an account on GitHub.
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8, 96–104 (2016). Article CAS PubMed PubMed Central Google Scholar Boussouar, A. et al. Netrin-1 and its receptor DCC are causally implicated in melanoma progression. Cancer Res. 80, 747–756 (2020). Article CAS PubMed Google Scholar Grandin, M. et al. Structural decoding of the...
MEF2 plays central roles in the transmission of extracellular signals to the genome and in the activation of genetic programs that control cell differentiation, proliferation, morphogenesis, survival, and apoptosis of a wide range of cell types [104,105]. MEF2D acts as a developmental transcription...