Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor. Am J Pathol. 1999;154(6):1763-1775.Hoyle GW, Li J, Finkelstein JB et al. Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice ...
1.A pathological condition of the lungs marked by an abnormal increase in the size of the air spaces, resulting in labored breathing and an increased susceptibility to infection. It can be caused by irreversible expansion of the alveoli or by the destruction of alveolar walls. ...
Technique to reduce air leaks after the resection of emphysematous lung Alveolar wall apoptosis causes lung destruction and emphysematous changes. Bronchial fenestration improves expiratory flow in emphysematous human lungs Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes ...
The p53 signaling pathway may be important for the pathogenesis of emphysematous changes in the lungs of smokers. Polymorphism of p53 at codon 72 is known to affect apoptotic effector proteins, and the polymorphism of mouse double minute 2 homolog (MDM2) single nucleotide polymorphism (SNP)309 is...
Recent evidence indicates that epithelial or endothelial apoptosis may be involved in the pathogenesis of emphysema. Here, we describe the induction of emphysematous changes, including airspace enlargement, alveolar wall destruction, and enhanced lung distensibility, in mice receiving a single intratracheal...
BACKGROUND: The p53 signaling pathway may be important for the pathogenesis of emphysematous changes in the lungs of smokers. Polymorphism of p53 at codon 72 is known to affect apoptotic effector proteins, and the polymorphism of mouse double minute 2 homolog (MDM2) single nucleotide polymorphism ...
Emphysematous pyelonephritis is an uncommon, life-threatening condition in which bubble-like collections of gas develop in the renal parenchyma, particularly in areas of coagulative necrosis, and extend into the perinephric space or retroperitoneum or both. From: Diagnostic Pathology of Infectious ...
Further highlighting the possibility of impaired elastogenesis, the postmortem lungs of two SIOD patients showed enlarged air spaces or emphysematous changes, a common feature in disorders of elastogenesis[7, 30, 31]. Given these observations, we hypothesized that osteopontin deficiency and/or impaired...
Immunohistochemical studies in control mice demonstrated that collagen fibers in the alveolar walls and ducts of the normal mouse lungs consist mainly of type III collagen. In the transgenic and hybrid mice, the emphysematous changes, which developed, were associated with a marked decrease in type ...
Immunohistochemical studies in control mice demonstrated that collagen fibers in the alveolar walls and ducts of the normal mouse lungs consist mainly of type III collagen. In the transgenic and hybrid mice, the emphysematous changes, which developed, were associated with a marked decrease in type ...