The Emmphenotype is associated with a rare deficiency of PIGG, potentially defining a new Emm blood group system composed of EtNP bound to mannose, part of the GPI-anchor. The results are consistent with the known PI-linked association of the Emm antigen, and may explain the production of ...
DNA damage and repair can have a key role in cancer therapy-induced neurotoxicity; to establish that such a phenomenon exists, Englander’s group demonstrated the role of APE1/Ref-1 in chemotherapy-induced peripheral neuropathy (CIPN). Peripheral nervous system (PNS) neurons were shown to be vu...
Here, we reported that homozygous null alleles of PIGG, a gene involved in GPI modification, are responsible for the rare Emm-negative blood phenotype. Using a panel of K562 cells defective in both the GPI-transamidase and GPI remodeling pathways, we demonstrate that the Emm antigen, whose ...
Here, the inventors reported that homozygous null alleles of PIGG, a gene involved in GPI modification, are responsible for the rare Emm-negative blood phenotype. Using a panel of K562 cells defective in both the GPI-transamidase and GPI remodeling pathways, they demonstrate that the Emm antigen...
At 16 days old, her antibiotic treatment was ended because of negative results of bacterial cultures of her blood and cerebrospinal fluid. The patient and her mother recovered without any sequelae. Group A Streptococcus is one of the most common origins of colds in children, represented by ...
The 62.5 % of the strains were notably tested positive for serum opacity factor SOF , whereas 37.5 % of the strains were tested negative. The antibiogram of S. pyogenes revealed sensitivity to cefotaxime 62.5 % , gentamicin 37.5 % , penicillin G 87. 5 % , clindamycin 87.5 % and ...
DEPTOR (DEP-domain containing mTOR-interacting protein) is a negative regulator of mTOR complexes, and it binds to mTOR via its PDZ domain (Peterson et al., 2009). When DEPTOR is activated by mTORC1 phosphorylation, the mTORC1-DEPTOR interaction became weak. RNAi-mediated knockdown of DEPTOR ...
The clinical signi- ficance of negative correlation between platelet count and AFA titer remains to be explained. In conclusion, we showed that AFA recognizes the recombinant filaggrin monomer which is not citrulli- nated as an antigen, explaining the variable sensi- tivity of AFA test. Antibody...
The rate of inhibition expressed by the formula is calculated from the measured values A, B, C thereof, and >=50% rate of inhibition is determined as antibody positive and <=50% rate as negative.SAWADA, TAKASHITAGUCHI, HIROKUNIMIYOSHI, ISAO...
A specific antibody against rabbit IgG was used as a negative control (lane 1 from the left in Figure 5B). Nuclear protein binding to oligo-YY-1 was reduced from 1 h until 6 h after treatment with PMA, and depended on the c-Jun level (Figure 4). The migrated bands were supershifted...