NGS revealed an EML4-NTRK3 fusion that was confirmed by Immunohistochemistry (IHC) and Fluorescence in situ hybridization (FISH). Despite having two potential targetable fusions, the patient did not respond to entrectinib, a multi-targeted pan-RTK, ROS1 and ALK inhibitor. analysis in blood or...
Infantile fibrosarcoma and congenital mesoblastic nephroma are tumors of infancy traditionally associated with the ETV6–NTRK3 gene fusion. However, a number of case reports have identified variant fusions in these tumors. In order to assess the frequenc
We report an interesting case of an NTRK fusion-positive NSCLC, exhibiting good response to entrectinib.doi:10.4103/jcrt.jcrt_231_21Batra, UllasNathany, ShrinidhiSharma, MansiJain, ParveenMehta, AnuragBansal, AbhishekJournal of Cancer Research & Therapeutics...
This prompted RNA-sequencing and the finding of a rare EML4::NTRK3 fusion. Clinical, histologic, and molecular findings are described, in addition to discussions regarding differential diagnoses and possible implications of the findings in clinical practice....
et al. Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy. Mod. Pathol. 31, 463-473 (2018).Church A.J., Calicchio M.L., Nardi V., Skalova A., ...
et al. Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy. Mod. Pathol. 31, 463-473 (2018).Church A.J., Calicchio M.L., Nardi V., Skalova A., Pinto A., Dillon D.A., Gomez-Fernandez C.R., Manoj N., H...
Characterization of a novel fusion gene EML4-NTRK3 in a case of recurrent congenital fibrosarcoma. Cold Spring Harb Mol Case Stud. 2015;1(1):a000471.Tannenbaum-Dvir S, Glade B J, Church A J, et al. Characterization of a novel fusion gene EML4-NTRK3 in a case of recurrent congenital ...
The EML4–NTRK3 fusion was identified in two cases of infantile fibrosarcoma (one of which was previously described), and in one case of congenital mesoblastic nephroma, demonstrating that the EML4–NTRK3 fusion is a recurrent genetic event in these related tumors. The growing spectrum of ...