mini review a section of the journal frontiers in pharmacology emerging roles of nucleoside transporters 来自 dx.doi.org 喜欢 0 阅读量: 32 作者: Claudio M Costa-Neto,Harry P De Koning,S Pérez-Torras,Maral Pastor-Anglada 摘要: cancer derived cell lines. Actually, CNT1 is a highly regulated...
Adenosine is a purine nucleoside and neuromodulator in the brain. It is also an essential component of energy production pathways, cellular metabolism, and gene regulation in brain cells. The levels of intracellular and extracellular adenosine are thus tightly controlled by a handful of proteins (...
Several classes of marketed drugs target well-known SLC transporters, such as neurotransmitter transporters, and human genetic studies have provided powerful insight into the roles of more-recently characterized SLC transporters in both rare and common diseases, indicating a wealth of new therapeutic ...
125,126 A divergent pioneering study demonstrated that an equilibrative nucleoside transporter 1 (ENT1) inhibitor activates brown adipose tissue (BAT) and thus might be utilized as an anti-obesity agent.127 Furthermore, pharmacological inhibition of mitochondrial pyruvate carriers was shown to enhance ...
[227]. However, current research is limited to the main metabolic pathways involved. The roles of other metabolic pathways, such as cholesterol metabolism, and some immune cells, such as natural killer (NK) and CD4+ T cells, are still unclear, and the role of metabolic reprogramming in ...
Animal models of disseminated rickettsiosis caused by intra venous R. conorii or R. australis infection in C3H/HeN or C57BL/6 mice, respectively, have revealed the cru- cial roles of T‑ and B‑cell responses against rickettsiae (FIG. 3). Experiments with mice that were ...
The lysed vesicles contained transferrin receptor and had many activities that were characteristic of the reticulocyte plasma membrane and were reduced or absent in mature erythrocytes. These activities include acetylcholinesterase, cytochalasin B binding (glucose transporter), nucleoside binding (i.e., ...
Animal models of disseminated rickettsiosis caused by intra venous R. conorii or R. australis infection in C3H/HeN or C57BL/6 mice, respectively, have revealed the cru- cial roles of T‑ and B‑cell responses against rickettsiae (FIG. 3). Experiments with mice that were ...
More recently, combinatorial approaches have been used to unravel both the novel roles of the SOS pathway and the functions of other complex regulatory networks that regulate ion homeostasis in Arabidopsis. This review focuses on the currently known and suggested functions of the SOS pathway in ion...
Type II transmembrane serine proteases (TTSPs), including TMPRSS2, TMPRSS3, DESC-1, MSPL, TMPRSS11a, are a family of serine proteases that are anchored to the cell membrane. These proteases play essential roles in various physiological processes, including digestion, immune response, and tissue...