The development and use of human embryonic stem cells (hESCs) in regenerative medicine have been revolutionary, offering significant advancements in treating various diseases. These pluripotent cells, derived from early human embryos, are central to modern biomedical research. However, their application is...
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Cardiomyocyte transplantation after heart attack improves contractile function in monkeys. Pluripotent stem cell–derived cardiomyocyte grafts can remuscularize substantial amounts of infarcted myocardium and beat in synchrony with the heart, but in some
We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while maintaining expression of markers characteristic of pluripotent primate cells. Human ES cells express the transcription factor Oct...
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPS cells) have the potential to provide such a source of cells because of their ability to differentiate into all somatic cells and their seemingly unlimited proliferative capability. In this...
View PDFSummary It has been proposed that human embryonic stem cells could be used to provide an inexhaustible supply of differentiated cell types for the study of disease processes. Although methods for differentiating embryonic stem cells into specific cell types have become increasingly sophisticated,...
The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use of hES cells in therapeutic applications. Of great interest are organs derived from definitive endoderm, such as the pancreas. We have foc...
Human embryonic stem (ES) cells hold great promise for medicine and science. The transcriptome of human ES cells has been studied in detail in recent years. However, no systematic analysis has yet addressed whether gene expression in human ES cells may be regulated in chromosomal domains, and ...
Embryonic stem cells 专利名称：Embryonic stem cells 发明人：Benjamin Eithan Reubinoff,Martin Frederick Pera,Chui-Yee Fong,Alan Osborne Trounson,Ariffeen Bongso 申请号：US09436164 申请日：19991109 公开号：US06875607B1 公开日：20050405 专利内容由知识产权出版社提供 摘要：The present invention relates to ...
adultsomaticcellstoESC-likecells,aprocesstermedreprogramming.ThisisaratherappealingchoiceforgeneratingpluripotentstemcellssinceitovercomesethicalissuesconcerningtheuseofdevelopingembryosandiPSCcanbegeneratedfrompatient-speci,cordisease-speci,ccellsfordownstreamapplications.Thepurposeofthebook“Pluripotentstemcells:Methodsand...