We review the semiparametric approach previously proposed by Kong and Lee and extend it to a case in which the dose-effect curves follow the Emax model instead of the median effect equation. When the maximum effects for the investigated drugs are different, we provide a procedure to obtain the...
In general, the Sigmoid 3-parameter equation forces thecalculated Emax towards the maximal experimentally observed value regardless of whether a `true' Emax has been reached. Conversely, the Hill 3-parameter equation extrapolates the data set tocalculate Emax and EC50 values that are closer to ...