Definition The mammalian elongin BC complex is a heterodimer, composed of the 118 amino acid, ubiquitin-like elongin B protein and the 112 amino acid elongin C protein. The elongin BC complex interacts through a short, degenerate BC-box motif with multiple proteins, including the transcription ...
Here we refer to the trimeric complex as Elongin. ELOA consists of a TFIIS N-terminal domain (TND)24, an unstructured middle region, a predicated Elongin A superfamily domain and an unstructured C-terminal region25. Studies of rat Elongin showed that ELOA interacts with the ELOB–ELOC sub...
The elongin B and C proteins were initially identified as positive regulatory subunits of the three-subunit elongin complex, which is one of several transcription factors capable of controlling the activity of the RNA polymerase II elongation complex. The three-subunit elongin complex was originally pu...
Together, Elongin B (ELOB) and Elongin C (ELOC) form a heterodimer that serves as the regulatory subunit for the Elongin complex--a general transcription elongation factor that increases RNA Polymerase II transcription through template-encoded arresting sites. The ELOB/ELOC complex also binds to ...
The elongin BC complex has recently been shown to be a potential target for regulation by the product of the von Hippel–Lindau (VHL) tumor suppressor gene (157, 158). The VHL gene is mutated in families with VHL disease, a rare genetic disorder (incidence ~ 1 in 36,000) that predispos...
人VHL/ELONGINB/ELONGINC COMPLEX 复合物, TAG FREE 中文别名: 人VHL/ELONGINB/ELONGINC COMPLEX 复合物, TAG FREE CBNumber: CB813746120 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 人VHL/ELONGINB/ELONGINC COMPLEX 复合物, TAG FREE化学性质 ...
Elongin BC Complex 来自 Springer 喜欢 0 阅读量: 53 作者:RC Conaway,JW Conaway 摘要: Definition The mammalian elongin BC complex is a heterodimer, composed of the 118 amino acid, ubiquitin-like elongin B protein and the 112 amino acid elongin C protein. The elongin BC complex interacts ...
The Elongin complex regulates the rate of RNA polymerase II (RNAPII) transcription elongation by releasing the transient pausing of RNAPII at multiple sites along the DNA. TCEB3/Elongin A is the transcriptionally active subunit, while Elongin B and C subunits play a regulatory role (3,4...
The VBC (VHL-elongin B-elongin C) complex was identified in association with the VHL (von Hippel-Lindau) tumor-suppressor protein. The structure of this complex is similar to that of the SCF complex. The substrate (transcription factor hypoxia-inducible factor 1α, HIF1-α) binds to the VH...
中文名称: 人VHL/ELONGINB/ELONGINC COMPLEX 复合物, TAG FREE 中文同义词: 人VHL/ELONGINB/ELONGINC COMPLEX 复合物, TAG FREE 英文名称: VBC 英文同义词: VBC CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览VBC国外供应商 中国供应商 VBC 推荐供应商 建议您优先选择企...